Selumetinib With or Without Temsirolimus in Treating Patients With Metastatic, Recurrent, or Locally Advanced Soft Tissue Sarcoma That Cannot Be Removed By Surgery

PRIMARY OBJECTIVES:

I. Compare the progression-free survival of the MEK inhibitor, AZD6244 (selumetinib) alone,
and the combination of AZD6244 and a mammalian target of rapamycin inhibitor (mTORi),
temsirolimus (CCI-779) in patients with recurrent metastatic or recurrent locally
unresectable soft-tissue sarcomas.

SECONDARY OBJECTIVES:

I. Determine the rates of apoptosis, autophagy, and proliferation with AZD6244 alone, and in
combination with temsirolimus by immunohistochemistry in tumor and surrogate skin tissue
biopsies. (exploratory) II. Assess the activation status of protein kinase B (Akt), 5E-BP1,
eukaryotic translation initiation factor 4 gamma, 1 (eIF-4G), and ribosomal protein S6
kinase (S6K) in tumor biopsy samples and surrogate skin tissue biopsy samples.(exploratory)
III. Assess inhibition of activated mitogen-activated protein kinase 1/2 (ERK1/2) in
stimulated peripheral blood mononuclear cells. (exploratory) IV. Assess response by Choi
criteria. V. Compare the response rate and 4-month progression-free survival (PFS) rate in
patients treated with these regimens.

VI. Compare the response rate, 4-month PFS rate and toxicity of AZD6244 alone and in
combination with temsirolimus.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM I: Patients receive selumetinib orally (PO) twice daily on days 1-28 and temsirolimus
intravenously (IV) over 30-60 minutes on days 1, 8, 15, and 22.

ARM II: Patients receive selumetinib as in arm I. Patients who experience disease
progression may cross over to arm I.

In both arms, courses repeat every 28 days in the absence of disease progression or
unacceptable toxicity.

After completion of study therapy, patients are followed up for 30 days.

Inclusion Criteria:

- Patients must have had histologic verification of soft-tissue sarcoma at original
diagnosis (GIST subtype is eligible)

- Patients must have metastatic (de novo or recurrent) or locally advanced,
unresectable disease; patients must have measurable disease, defined as at least one
lesion that can be accurately measured in at least one dimension (longest diameter to
be recorded) as >= 20 mm with conventional techniques or as >= 10 mm with spiral CT
scan

- ECOG 0-2 (Karnofsky >= 50%)

- Patients may have received 0-2 prior cytotoxic chemotherapeutic regimens for
metastatic or recurrent disease (single-agent or combination chemotherapies)

- Estimated life expectancy > 12 weeks

- Peripheral absolute neutrophil count (ANC) >= 1000/uL

- Platelet count >= 100,000/uL (transfusion independent)

- Hemoglobin >= 8.0 gm/dL (may receive RBC transfusions)

- Creatinine =< 1.5 x upper institutional limits of normal, or calculated creatinine
clearance >= 45mL/min, based on the Cockcroft-Gault formula

- Bilirubin (sum of conjugated + unconjugated) =< 1.5 x upper limit of normal (ULN) for
age

- SGPT (ALT) =< 5 x upper limit of normal (ULN) for age

- No evidence of dyspnea at rest, no exercise intolerance

- Pulse oximetry > 94% if there is clinical indication for determination

- For women: must be surgically sterile, postmenopausal, or compliant with a medically
approved contraceptive regimen (for example, intrauterine device [IUD], birth control
pills, or barrier device) during and until 4 weeks after the last dose of study
treatment; must have a negative serum or urine pregnancy test within 7 days before
study enrollment, and must not be breast-feeding; should a woman become pregnant or
suspect she is pregnant while she or her partner participating in this study, the
patient should inform her treating physician immediately; for men: must be surgically
sterile or compliant with a contraceptive regimen during and for 16 weeks after the
treatment period; please note that the AZD6244 manufacturer recommends that adequate
contraception for male patients should be used for 16 weeks post-last dose due to
sperm life cycle

- All patients must sign a written informed consent

Exclusion Criteria:

- Patients with pediatric-type sarcomas (Ewing's or primitive neuroectodermal tumor,
rhabdomyosarcoma, and desmoplastic small round cell tumor)

- Concomitant Medications

- Growth factor(s): growth factors that support platelet or white cell number or
function must not have been administered within the past 7 days

- Steroids: patients with CNS tumors who have not been on a stable or decreasing
dose of dexamethasone for the past 7 days

- Investigational Drugs: patients who are currently receiving another
investigational drug

- Anti-cancer Agents: patients who are currently receiving other anti-cancer
agents; at least 3 weeks must have elapsed since prior chemotherapy or radiation
(6 weeks for mitomycin-C and nitrosureas)

- Patients with known brain metastases should be excluded from this clinical trial
because of their poor prognosis and because they often develop progressive neurologic
dysfunction that would confound the evaluation of neurologic and other adverse events

- History of allergic reactions attributed to compounds of similar chemical or biologic
composition to AZD6244

- Previous MEK inhibitor use

- Patients with QTc interval > 450 msecs or other factors that increase the risk of QT
prolongation or arrhythmic events (e.g., heart failure, hypokalemia, family history
of long QT interval syndrome); this may be determined by either Bazett's correction
(QTc =QT/RR0.5) or Friderica's correction (QTc = QT/RR0.33); QTc exclusion > 450 msec
requires calculation according to both formulas

- Patients unable to swallow the AZD6244 capsules are ineligible

- Refractory nausea and vomiting, chronic gastrointestinal diseases (e.g., inflammatory
bowel disease), or significant bowel resection that would preclude adequate
absorption

- Uncontrolled intercurrent illness including, but not limited to, uncontrolled,
ongoing or active infection or psychiatric illness/social situations that would limit
compliance with study requirements

- Pregnant women are excluded from this study because the effects of AZD6244 on the
developing human fetus at the recommended therapeutic dose are unknown; because there
is an unknown but potential risk for adverse events in nursing infants secondary to
treatment of the mother, breastfeeding should be discontinued if the mother is
treated with AZD6244

- HIV-positive patients on combination antiretroviral therapy are ineligible because of
the potential for pharmacokinetic interactions with AZD6244; appropriate studies will
be undertaken in patients receiving combination antiretroviral therapy when indicated

- Patients who in the opinion of the investigator may not be able to comply with the
safety monitoring requirements of the study

- Prior cardiac history of uncontrolled hypertension, New York Heart Association (NYHA)
Classification >= class II, current or prior cardiomyopathy, baseline LVEF < 50%,
ongoing atrial fibrillation, recent myocardial infarction or unstable ischemic heart
disease

- Concomitant Strong CYP1A2 or CYP3A4 inducers and/or inhibitors; prior treatment with
an mTOR inhibitor for recurrent soft-tissue sarcoma