Estrogen and Perimenopausal Depression
| Status: | Recruiting |
|---|---|
| Conditions: | Depression, Major Depression Disorder (MDD), Women's Studies |
| Therapuetic Areas: | Psychiatry / Psychology, Pulmonary / Respiratory Diseases, Reproductive |
| Healthy: | No |
| Age Range: | 40 - 60 |
| Updated: | 4/2/2016 |
| Start Date: | October 2004 |
| Contact: | Melinda L. Morgan, Ph.D. |
| Email: | melinda@ucla.edu |
| Phone: | 310-825-5028 |
Dose Response Effects of Estrogen Augmentation in Mood & Memory in Perimenopausal Depression
During perimenopause (the time just prior to menopause), women often notice many biological,
psychological, and social changes. In particular, some women experience depressive symptoms
during perimenopause that are severe enough to warrant antidepressant medication. Whether or
not women with perimenopausal depression respond to antidepressant medication may depend on
the level of estrogen in their blood. We would like to investigate whether estrogen will
help the women who only partially respond to antidepressant medications. We also want to
examine how different doses of estrogen may affect individuals differently.
psychological, and social changes. In particular, some women experience depressive symptoms
during perimenopause that are severe enough to warrant antidepressant medication. Whether or
not women with perimenopausal depression respond to antidepressant medication may depend on
the level of estrogen in their blood. We would like to investigate whether estrogen will
help the women who only partially respond to antidepressant medications. We also want to
examine how different doses of estrogen may affect individuals differently.
Inclusion Criteria:
- Clinical Diagnosis of Unipolar Major Depression, currently taking antidepressants
- HAM-D between 10 and 17
Exclusion Criteria:
- History of Psychosis, breast cancer, smoking, dementia, clotting disorders
- Current substance abuse
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