Collection of Blood, Bone Marrow, Leukapheresis, and Tissue Biopsy Samples From Patients and Their Family Members for Center for Human Immunology, Autoimmunity, and Inflammatory Diseases Laboratory Research Studies
| Status: | Terminated |
|---|---|
| Conditions: | Infectious Disease |
| Therapuetic Areas: | Immunology / Infectious Diseases |
| Healthy: | No |
| Age Range: | 2 - Any |
| Updated: | 9/22/2018 |
| Start Date: | July 1, 2010 |
| End Date: | September 18, 2018 |
Collection of Blood, Bone Marrow, Leukapheresis, and Tissue Biopsy Samples From Patients and Their Family Members for Center for Human Immunology, Autoimmunity, and Inflammatory Diseases (CHI) Laboratory Research Studies
Background:
- The Center for Human Immunology, Autoimmunity, and Inflammatory Diseases (CHI) is
conducting a variety of laboratory research experiments that require blood, bone marrow,
urine, stool, and/or tissue samples from patients with a diagnosis of an immunologic,
autoimmune, or inflammatory disorder, as well as from their healthy relatives. Donated
samples will be sent to the CHI laboratory at the National Institutes of Health to be used in
research that may provide more information on the changes in the immune system caused by
these specific disorders.
Objectives:
- To collect blood, leukapheresis cells, bone marrow, urine, stool, cheek swab, and tissue
samples from patients with immune-mediated and inflammatory diseases, as well as from family
members, for ongoing exploratory research studies.
Eligibility:
- Individuals at least 2 years of age who have been diagnosed with an immune-mediated or
inflammatory disease, or have signs or symptoms of an immune or inflammatory disease
without a formal diagnosis.
- Immediate family members (parent, child, sibling, grandchild) of the above mentioned
individuals.
Design:
- Participants will be screened with a complete medical history, physical examination, and
blood and urine samples.
- Participants will provide blood, urine, stool, cheek swab, and tissue samples as
required by the study researchers.
- Participants who have immune or inflammatory diseases will also provide blood and bone
marrow samples collected through biopsies and leukapheresis (to collect specific blood
cells).
- Adult relatives will provide additional samples through more invasive procedures such as
leukapheresis and bone marrow biopsies. Child relatives (between 2 and 18 years of age)
will not undergo these invasive procedures.
- No treatment will be provided as part of this protocol.
- The Center for Human Immunology, Autoimmunity, and Inflammatory Diseases (CHI) is
conducting a variety of laboratory research experiments that require blood, bone marrow,
urine, stool, and/or tissue samples from patients with a diagnosis of an immunologic,
autoimmune, or inflammatory disorder, as well as from their healthy relatives. Donated
samples will be sent to the CHI laboratory at the National Institutes of Health to be used in
research that may provide more information on the changes in the immune system caused by
these specific disorders.
Objectives:
- To collect blood, leukapheresis cells, bone marrow, urine, stool, cheek swab, and tissue
samples from patients with immune-mediated and inflammatory diseases, as well as from family
members, for ongoing exploratory research studies.
Eligibility:
- Individuals at least 2 years of age who have been diagnosed with an immune-mediated or
inflammatory disease, or have signs or symptoms of an immune or inflammatory disease
without a formal diagnosis.
- Immediate family members (parent, child, sibling, grandchild) of the above mentioned
individuals.
Design:
- Participants will be screened with a complete medical history, physical examination, and
blood and urine samples.
- Participants will provide blood, urine, stool, cheek swab, and tissue samples as
required by the study researchers.
- Participants who have immune or inflammatory diseases will also provide blood and bone
marrow samples collected through biopsies and leukapheresis (to collect specific blood
cells).
- Adult relatives will provide additional samples through more invasive procedures such as
leukapheresis and bone marrow biopsies. Child relatives (between 2 and 18 years of age)
will not undergo these invasive procedures.
- No treatment will be provided as part of this protocol.
BACKGROUND
Clinical investigators in the Center for Human Immunology, Autoimmunity, and Inflammatory
Diseases (CHI) study the pathophysiology of a wide variety of immune-mediated and
inflammatory diseases. One of the goals of the CHI is to better understand these diseases and
to refine therapeutic approaches used in their management based on knowledge of the
underlying pathophysiologies. This requires samples from patients with immune-mediated and
inflammatory diseases for such clinical and laboratory assessments. Collection of samples
from family members is necessary to identify genetic components of specific conditions.
We expect the great majority of publications from the Center for Human Immunology,
Autoimmunity, and Inflammatory Diseases (CHI) over the next several decades will be generated
from exploratory laboratory research studies done using blood and bone marrow and other
tissue samples from such patients and their family members. These publications are expected
to number in the hundreds. Ongoing and future research projects depend on the ready
availability of samples of blood, tissue, leukapheresed cells, and bone marrow from patients
for in vitro studies.
OBJECTIVE
To provide a mechanism for collection of blood, bone marrow, leukapheresis cells, urine,
stool, buccal mucosa and/or tissue samples from patients with immune-mediated and
inflammatory diseases, as well as from family members for ongoing exploratory research
studies.
STUDY DESIGN
This study is not a treatment protocol. This is a sample and clinical data procurement
protocol.
All subjects with conditions of interest seen at the NIH Clinical Center will first be
enrolled onto CHI protocol 09-H-0201 Screening protocol for subjects being evaluated for
Center for Human Immunology, Autoimmunity, and Inflammatory Diseases (CHI) protocols.
Patients who require specific medical intervention will be enrolled on and receive treatment
under another NIH or CHI Clinical Center protocol or will be under the care of their home
health care provider. In exceptional cases in which it is not possible for patients to travel
to the Clinical Center, they may be allowed the option of giving consent to provide samples
for research studies, including genetic analyses, performed on blood, buccal mucosa, bone
marrow, and tissue samples sent through their local physician without enrolling onto
09-H-0201. Information will be obtained retrospectively by review of medical records and
examination of archived materials and/or prospectively by clinical examinations and
laboratory tests. The protocol is written for an indefinite period of time with subject
accrual to occur both at the NIH Clinical Center or through home health care providers (off
site).
Clinical investigators in the Center for Human Immunology, Autoimmunity, and Inflammatory
Diseases (CHI) study the pathophysiology of a wide variety of immune-mediated and
inflammatory diseases. One of the goals of the CHI is to better understand these diseases and
to refine therapeutic approaches used in their management based on knowledge of the
underlying pathophysiologies. This requires samples from patients with immune-mediated and
inflammatory diseases for such clinical and laboratory assessments. Collection of samples
from family members is necessary to identify genetic components of specific conditions.
We expect the great majority of publications from the Center for Human Immunology,
Autoimmunity, and Inflammatory Diseases (CHI) over the next several decades will be generated
from exploratory laboratory research studies done using blood and bone marrow and other
tissue samples from such patients and their family members. These publications are expected
to number in the hundreds. Ongoing and future research projects depend on the ready
availability of samples of blood, tissue, leukapheresed cells, and bone marrow from patients
for in vitro studies.
OBJECTIVE
To provide a mechanism for collection of blood, bone marrow, leukapheresis cells, urine,
stool, buccal mucosa and/or tissue samples from patients with immune-mediated and
inflammatory diseases, as well as from family members for ongoing exploratory research
studies.
STUDY DESIGN
This study is not a treatment protocol. This is a sample and clinical data procurement
protocol.
All subjects with conditions of interest seen at the NIH Clinical Center will first be
enrolled onto CHI protocol 09-H-0201 Screening protocol for subjects being evaluated for
Center for Human Immunology, Autoimmunity, and Inflammatory Diseases (CHI) protocols.
Patients who require specific medical intervention will be enrolled on and receive treatment
under another NIH or CHI Clinical Center protocol or will be under the care of their home
health care provider. In exceptional cases in which it is not possible for patients to travel
to the Clinical Center, they may be allowed the option of giving consent to provide samples
for research studies, including genetic analyses, performed on blood, buccal mucosa, bone
marrow, and tissue samples sent through their local physician without enrolling onto
09-H-0201. Information will be obtained retrospectively by review of medical records and
examination of archived materials and/or prospectively by clinical examinations and
laboratory tests. The protocol is written for an indefinite period of time with subject
accrual to occur both at the NIH Clinical Center or through home health care providers (off
site).
- INCLUSION CRITERIA
Affected Adults
- The subject carries the diagnosis of an immune-mediated or inflammatory disease, or
has signs or symptoms of an immune or inflammatory disease without a formal diagnosis.
- Age 18 years and older (no upper limit)
Affected Children
- The subject carries the diagnosis of an immune-mediated or inflammatory disease, or
has signs or symptoms of an immune or inflammatory disease without a formal diagnosis.
- Age 2 years and older (no upper limit)
Unaffected Child Relatives
- Immediate family members (child, sibling, grandchild) of individuals included under
item (Affected Adult)
- Subjects over 2 years of age may (but < 18 years of age) be seen for initial
evaluations, genetic studies, or research blood specimens, or may send blood or buccal
samples for genetic testing only. Unaffected family members will not be asked to
undergo leukapheresis, bone marrow aspirations and biopsies, or other invasive
procedures.
Unaffected Adult Relatives
- Immediate family members (parent, child, sibling, grandchild) of individuals included
under item (Affected Adult)
- Subjects over 18 years of age may be seen for initial evaluations, genetic studies, or
research blood specimens, or may send blood or buccal samples for genetic testing
only. Unaffected family members will not be asked to undergo leukapheresis, bone
marrow aspirations and biopsies, or other invasive procedures.
EXCLUSION CRITERIA: (All groups)
- Subjects or their parents or guardians who are unable to comprehend the
investigational nature of the procedure. The subject or the subject s guardian is
unable to understand the investigational nature of the study and provide informed
consent after initial counseling by clinical staff. Only adults capable of signing
consent will be eligible. Separate consent forms for all interventional or surgical
procedures will be obtained after explanation of the specific procedure.
- Pregnant unaffected relatives will be excluded.
- Subjects not willing to participate in the genetic analysis and whole genomic analysis
portion of this study.
We found this trial at
1
site
9000 Rockville Pike
Bethesda, Maryland 20892
Bethesda, Maryland 20892
Phone: 800-411-1222
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