A Surgical Approach to the Management of Type II Diabetes Mellitus in Patients With a BMI Between 25-35 kg/m2
| Status: | Completed |
|---|---|
| Conditions: | Diabetes |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 21 - 55 |
| Updated: | 5/5/2014 |
| Start Date: | September 2010 |
| End Date: | December 2012 |
| Contact: | Anna Tenorio |
| Email: | anna.cecilia.s.tenorio@uth.tmc.edu |
| Phone: | 713 486 1350 |
The purpose of the study is to determine if by performing surgery we can cure Type II
Diabetes.
The surgical procedures:
1. a sleeve gastrectomy, cutting out a portion of the stomach, which provides restriction
of caloric intake and rapid gastric emptying.
2. ileal transposition which involves repositioning a 150cm segment of the ileum into the
jejunum causing improved glucose homeostasis.
Diabetes.
The surgical procedures:
1. a sleeve gastrectomy, cutting out a portion of the stomach, which provides restriction
of caloric intake and rapid gastric emptying.
2. ileal transposition which involves repositioning a 150cm segment of the ileum into the
jejunum causing improved glucose homeostasis.
Inclusion Criteria:
- age- 21-55 years.
- Body Mass Index between 25-35 kf/m2.
- currently being treated for type 2 diabetes mellitus with oral hypoglycemic, insulin
or both for the at least 3 years.
- Documented HbA1c>7.5% for at least 3 months.
- Stable weight for 3 months (+/-)
- Evidence of stable medical treatment for diabetes over the past 12 months.
- Able to provide informed consent -Female subject agrees to participate in accepted
birth control methods -
Exclusion Criteria:
- Type I diabetes/juvenile onset
- C-Peptid levels below 1.0 ng/ml
- Previous major upper abdominal surgery
--Pregnant or plans to become pregnant with in the next 12 months
- Current Malignancy
- Severe pulmonary, cardia, or renal disease
- Eating disorders such as bulimia or binge-eating
- Severe mental health disorders such as schizophrenia and bipolar disorder
- Obesity due to other metabolic disorders
- taking appetite suppressants
- currently abusing illicit drugs,alcohol or using tobacco products
- Unable to provide informed consent
- Unwillingness or unable to comply with study procedures
- any condition that deems them unsuitable for the study in the opinion of the
investigators
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