Cell Mediated Immunity in Older Adults

This study is to study the immune response to the flu vaccine in people 65 years old and
older. Only adults 65 years old and older and who are getting their flu vaccine are being
asked to join in this study. The investigators plan to enroll approximately 100 people in
this study in the 2010-2011 flu season. Vanderbilt is working with the Centers for Disease
Control and Prevention on this study.

There will be 5 study visits. Up to 4 tablespoons of blood from a vein will be obtained
prior to the flu shot. Return visits will be 1, 2, and 4 weeks later,with up to 4
tablespoons of blood drawn again. Patients will be randomized to receive either the standard
dose or the high dose flu vaccine. Both flu vaccines are FDA-approved.