A Pilot Study to Identify Biomarkers Associated With Chronic Traumatic Brain Injury
| Status: | Enrolling by invitation |
|---|---|
| Conditions: | Hospital, Neurology |
| Therapuetic Areas: | Neurology, Other |
| Healthy: | No |
| Age Range: | 18 - 70 |
| Updated: | 1/18/2019 |
| Start Date: | April 2010 |
| End Date: | August 2021 |
A Pilot Study to Identify Biomarkers Associated With Chronic TBI
The aim of this research is to determine if the biological fluids (blood/saliva) from chronic
brain-injured patients (both blast and non-penetrating TBI) contain reproducible protein
markers. To accomplish this two populations of chronic TBI patients who are receiving
treatment at The Institute for Research and Rehabilitation (TIRR): blast injury victims and
non-penetrating TBI will be studied. Using multiple proteomic approaches including mass
spectrometry, multiplex ELISAs, and antibody microarrays, as well as RNA profiling, the
investigators aim to identify biomarkers in the blood/saliva of patients suffering from
chronic TBI and to determine the similarities/differences between the blast and
non-penetrating injury groups. Identification of these biochemical changes will give insight
into the long-lasting changes associated with head injury, and may identify new targets for
treating the associated pathologies.
brain-injured patients (both blast and non-penetrating TBI) contain reproducible protein
markers. To accomplish this two populations of chronic TBI patients who are receiving
treatment at The Institute for Research and Rehabilitation (TIRR): blast injury victims and
non-penetrating TBI will be studied. Using multiple proteomic approaches including mass
spectrometry, multiplex ELISAs, and antibody microarrays, as well as RNA profiling, the
investigators aim to identify biomarkers in the blood/saliva of patients suffering from
chronic TBI and to determine the similarities/differences between the blast and
non-penetrating injury groups. Identification of these biochemical changes will give insight
into the long-lasting changes associated with head injury, and may identify new targets for
treating the associated pathologies.
Chronic TBI patients:
Inclusion Criteria
Have a history of head trauma manifesting in one or more of the following:
- Loss of consciousness
- Post-traumatic amnesia
- Focal neurologic deficits, seizure
- Persistent symptoms of increased arousal (e.g. difficulty falling or staying asleep,
anger and hypervigilance)
- Impairment in social, occupational, or other important areas of functioning (e.g.
problems with work and relationships.)
Exclusion Criteria
Inability to obtain informed consent and if they are non-communicative (i.e. in a
vegetative state).
Healthy volunteers:
Inclusion Criteria
- No significant medical history
- Take no medications (other than birth control pills)
- Fever free
- No history of head trauma or recent injury/infection
- No history of neurological or psychiatric disorders or alcohol or drug dependency.
Exclusion Criteria
- Inability to provide informed consent
- age/gender match not available in TBI cohort
We found this trial at
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