Analysis of Tumors From Patients With Inherited Cancers Having Had Two Surgeries (Primary + Recurrent, or 2 Separate Types of Cancer)

This study will recruit individuals with known BRCA1 and BRCA2 mutations or mutations in
similar cancer causing genes such as CHK2 or PALB2 who have had a cancer removed by surgery
or biopsied two or more times with available pathological blocks. We wish to enroll
individuals who have had more than one surgery or biopsy for cancer allowing us to obtain
tumor blocks from more than one time point. Such patients would include those with one cancer
which has recurred or more than one separate cancer. We will conduct a brief interview with
the subject to obtain personal information about medical and treatment history. In addition,
we will collect clinical information from their treating physician(s) to correlate molecular
findings with clinical responses to treatment and survival and recurrence data. We will
collect background clinical information and family history information and a copy of the
genetic test results documenting their cancer causing mutation. We will recruit only patients
with known BRCA1 or BRCA2 mutations or known mutations in other cancer causing genes such as
CHK2 or PALB2 and will not perform genetic testing on non-tumor tissue for any new
information on genetic susceptibility in patient samples. Enrolled subjects will donate a
blood sample that will be obtained locally and shipped to the research laboratory, and this
cost will be entirely covered by the research group.

Inclusion Criteria:

- Male or female

- Age 18 or older

- documented mutation in BRCA1, BRCA2 or other known cancer causing gene

- one or more cancer with available stored tissue blocks or slides

- willing to donate 16cc of blood

- able to understand English and provide informed consent

Exclusion Criteria:

- unable or unwilling to provide informed consent

- patient does not have tissue blocks available

- minor, under age 18