Dynamic Aspects of Amino Acid Metabolism



Status:Recruiting
Conditions:Renal Impairment / Chronic Kidney Disease
Therapuetic Areas:Nephrology / Urology
Healthy:No
Age Range:18 - 55
Updated:4/2/2016
Contact:Dwight Matthews, Ph.D.
Phone:1-802-646-8114

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This protocol seeks to define aspects of intestinal and hepatic uptake and metabolism of
several amino acids. The major hypothesis to be tested is that the splanchic bed (intestine
and liver) conserves essential amino acids and metabolites while synthesizing and
metabolizing nonessential amino acids. The aims of the study include defining the relative
roles of enteral and hepatic extraction/metabolism in the disposition of glutamate, alanine,
methionine and other amino acids. Emphasis will also be placed on studies of the
transamination of alpha-ketoisocaproic acid (KIC) to leucine since this reaction is of
potential importance in the design of nutritional regimens for patients with renal disease.


Inclusion Criteria:

- normal weight-for-height weight 50-80 kg

- normal physical activity

- no significant medical history

- healthy by medical exam and lab blood testing

Exclusion Criteria:

- subjects who exercise vigorously

- subjects who smoke
We found this trial at
1
site
85 S Prospect St
Burlington, Vermont 5405
(802) 656-3131
University of Vermont The University of Vermont combines faculty-student relationships most commonly found in a...
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Burlington, VT
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