Short (5 Days) Versus Long (14 Days) Duration of Antimicrobial Therapy for Acute Bacterial Sinusitis in Children



Status:Recruiting
Conditions:Sinusitis
Therapuetic Areas:Otolaryngology
Healthy:No
Age Range:1 - 10
Updated:4/21/2016
Start Date:November 2010
End Date:April 2016
Contact:Stacey Moyer, MSN
Email:scmoyer@pediatrics.wisc.edu
Phone:608-262-9531

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The investigators objective is to compare short course (5 days) to long course (14
days)antibiotics for the treatment of acute bacterial sinusitis in children. The
investigators hypothesize that short course therapy will lead to more frequent relapses of
sinusitis and will not reduce resistant organisms.


Inclusion Criteria:

1. children with nasal discharge (of any quality) or daytime cough (which may be worse
at night) or both persisting for 10 days or more without evidence of improvement.

2. families need to be English speaking

Exclusion Criteria:

1. used antibiotics within the last 15 days;

2. had symptoms for > 30 days;

3. have concurrent streptococcal pharyngitis or acute otitis media (as the standard
doses for both of these conditions is 10 days);

4. are allergic to penicillin;

5. have symptoms that suggest a complication due to acute bacterial sinusitis that
necessitates hospitalization, intravenous antibiotics or sub-specialty evaluation

6. been diagnosed with either immunodeficiency or anatomic abnormality of the upper
respiratory tract

7. history of recurrent acute sinusitis (more than 3 episodes in 6 months or 4 episodes
in a year)

8. history of chronic sinusitis (more than 90 days of respiratory symptoms in this or
the previous respiratory season)

9. girls who have begun menstruating
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Madison, Wisconsin 53715
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Madison, Wisconsin 53717
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