Effects of Tofacitinib (CP-690,550) on Magnetic Resonance Imaging (MRI)- Assessed Joint Structure In Early Rheumatoid Arthritis (RA)



Status:Completed
Conditions:Arthritis, Rheumatoid Arthritis
Therapuetic Areas:Rheumatology
Healthy:No
Age Range:18 - Any
Updated:11/30/-0001
Start Date:October 2010
End Date:December 2013
Contact:Pfizer CT.gov Call Center
Phone:1-800-718-1021

Use our guide to learn which trials are right for you!

An Exploratory Phase 2, Randomized, Double-Blind, Multicenter Study To Assess The Effects Of Tofacitinib (CP-690,550) On Magnetic Resonance Imaging Endpoints, In Methotrexate Naïve Subjects With Early Active Rheumatoid Arthritis


Evaluation of efficacy and safety of tofacitinib (CP-690,550) for the treatment of early
rheumatoid arthritis in adult patients with moderate to severe disease who are methotrexate
naïve. The efficacy will be evaluated by exploring the effects on joint structure assessed
by magnetic resonance imaging, x-rays and by standard clinical assessment.


Inclusion Criteria:

- Adult patients with moderate to severe early rheumatoid arthritis (< 2 years) who are
methotrexate and biologic disease modifying antirheumatic drug naive.

Exclusion Criteria:

- Pregnant or lactating patients;

- Patients with renal or hepatic impairment or other severe or progressing disease;

- Patients with contraindication to magnetic resonance imaging with gadolinium
contrast.
We found this trial at
10
sites
Daytona Beach, Florida 32114
2188
mi
from 91732
Daytona Beach, FL
Click here to add this to my saved trials
1227
mi
from 91732
Allen, TX
Click here to add this to my saved trials
Gilbert, Arizona 85234
363
mi
from 91732
Gilbert, AZ
Click here to add this to my saved trials
Huntington Beach, California 92646
28
mi
from 91732
Huntington Beach, CA
Click here to add this to my saved trials
Largo, Florida 33771
2118
mi
from 91732
Largo, FL
Click here to add this to my saved trials
Oklahoma City, Oklahoma 73104
1165
mi
from 91732
Oklahoma City, OK
Click here to add this to my saved trials
Ormond Beach, Florida 32174
2186
mi
from 91732
Ormond Beach, FL
Click here to add this to my saved trials
Pinellas Park, Florida 33782
2124
mi
from 91732
Pinellas Park, FL
Click here to add this to my saved trials
St. Petersburg, Florida 33710
2130
mi
from 91732
St. Petersburg, FL
Click here to add this to my saved trials
20
mi
from 91732
Upland, CA
Click here to add this to my saved trials