Effect of D-cycloserine on Treatment of Posttraumatic Stress Disorder (PTSD) in Youth
| Status: | Archived |
|---|---|
| Conditions: | Psychiatric |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | June 2010 |
| End Date: | June 2012 |
Effect of D-cycloserine on Treatment of PTSD in Youth
The purpose of this study is to show whether D-cycloserine in combination with cognitive
behavioral therapy (CBT) is more effective than CBT alone to reduce symptoms of
posttraumatic stress disorder (PTSD) in 7-12 year old children.
While most individuals with PTSD treated with cognitive behavioral therapy (CBT) show
improvement, they still have some enduring symptoms and functional impairment. Accordingly,
there is a need for treatment advances.
D-cycloserine (DCS), an antibiotic that has been used for over 50 years, has also been found
to have positive effects on cognition and anxiety. DCS was found to enhance learning and
memory, and also facilitates extinction of fear reactions. However, DCS only produces an
extinction effect when paired with behavioral training, not when simply given alone. Thus,
the medication only needs to be given for seven doses in this research and youth do not need
to take the medication long term. The research also includes a three-month follow-up
assessment.
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