Pharmacokinetic (PK) Study of Oral and IV TR-701 FA in Adolescent Patients

Inclusion Criteria:

- males and females, between 12 and 17 years of age, inclusive;

- receiving prophylaxis for or have a confirmed or suspected infection with Gram
positive bacteria and receiving concurrent antibiotic treatment with Gram positive
antibacterial activity

- in stable condition

- females must be premenarchal, surgically sterile, abstinent, or practicing an
effective method of birth control

- males will either be surgically sterile, abstinent, or practicing an effective method
of birth control

Exclusion Criteria:

- relevant history of seizures, clinically significant cardiac arrhythmia, cystic
fibrosis, moderate or severe renal impairment, or any physical condition that could
interfere with the interpretation of the study results

- any acute or chronic condition that, in the opinion of the Investigator, would limit
the patient's ability to complete and/or participate in this clinical study

- physician-diagnosed migraine headaches

- history of infection with hepatitis or other significant hepatic disease

- females who are pregnant or breast feeding