Microaspiration in Pulmonary Fibrosis
| Status: | Completed |
|---|---|
| Conditions: | Pulmonary |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - 100 |
| Updated: | 4/21/2016 |
| Start Date: | December 2009 |
| End Date: | June 2015 |
The Role of Microaspiration in Idiopathic Pulmonary Fibrosis
Hypothesis 1: Microaspiration, as diagnosed by bronchoalveolar lavage (BAL) pepsin, is
common in patients with IPF.
Hypothesis 2a: Baseline clinical variables and co-morbid conditions are risk factors for
microaspiration in patients with IPF.
Hypothesis 2b: Baseline biological variables reflecting alveolar epithelial injury and
inflammation are markers of microaspiration in IPF.
Hypothesis 3a: Microaspiration will lead to a more rapid rate of decline in pulmonary
function.
Hypothesis 3b: Microaspiration will lead to higher rates of urgent medical care use (i.e.
unscheduled clinic visit, emergency room visit, or hospitalization).
common in patients with IPF.
Hypothesis 2a: Baseline clinical variables and co-morbid conditions are risk factors for
microaspiration in patients with IPF.
Hypothesis 2b: Baseline biological variables reflecting alveolar epithelial injury and
inflammation are markers of microaspiration in IPF.
Hypothesis 3a: Microaspiration will lead to a more rapid rate of decline in pulmonary
function.
Hypothesis 3b: Microaspiration will lead to higher rates of urgent medical care use (i.e.
unscheduled clinic visit, emergency room visit, or hospitalization).
Inclusion Criteria:
- Diagnosis of IPF
- Ability ot provide informed consent
Exclusion Criteria:
- History of fundoplication or other gastroesophageal surgery
- Too ill to undergo bronchoscopy in the opinion of the investigator
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