Mechano-physiological Approach to Anorectal Function
| Status: | Terminated |
|---|---|
| Conditions: | Constipation |
| Therapuetic Areas: | Gastroenterology |
| Healthy: | No |
| Age Range: | 18 - 80 |
| Updated: | 5/27/2018 |
| Start Date: | February 2006 |
| End Date: | May 2011 |
Mechano-physiological Approach to Normal Anorectal Function and the Classification of Defecatory Disorders
We hypothesize that defecatory disorders can be described in mechanical terms which would
allow a mechanistic description of disorders which would in turn allow better directed
biofeedback mechanisms to treat disorders of defecation.
allow a mechanistic description of disorders which would in turn allow better directed
biofeedback mechanisms to treat disorders of defecation.
Disorders of defecation are very common and the process of defecation remains poorly
described. This results in a limited approach to treatment of patients, with limited success.
This study will simultaneously measure multiple components of the process of defecation - the
abdominal wall and perineal muscle activity, the pressure within the rectum and in the anal
canal and the change in shape of the anorectal region of the colon, in order to develop a
biomechanical model which can describe the normal and abnormal defecatory process. It is
anticipated that, by understanding the process in these terms will allow a new approach to
categorizing and describing defecation problems which in turn will lead to more specific
approaches of treatment which will be tailored to individual patients. These parameters will
compared in volunteers with no defecatory disorders and patients with defecatory disorders
who are being referred for defecography as part of their clinical evaluation.
described. This results in a limited approach to treatment of patients, with limited success.
This study will simultaneously measure multiple components of the process of defecation - the
abdominal wall and perineal muscle activity, the pressure within the rectum and in the anal
canal and the change in shape of the anorectal region of the colon, in order to develop a
biomechanical model which can describe the normal and abnormal defecatory process. It is
anticipated that, by understanding the process in these terms will allow a new approach to
categorizing and describing defecation problems which in turn will lead to more specific
approaches of treatment which will be tailored to individual patients. These parameters will
compared in volunteers with no defecatory disorders and patients with defecatory disorders
who are being referred for defecography as part of their clinical evaluation.
Controls
Inclusion Criteria:
- Women
- No defecatory problems
- On no medication which affect bowel habits
Exclusion Criteria:
- Pregnancy
Patients
Inclusion Criteria:
- Difficulty in defecation
- Women
Exclusion criteria:
- Pregnancy
- Medication which can affect bowel movement
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