Tissue, Blood, and Body Fluid Sample Collection From Patients With Hematologic Cancer

OBJECTIVES:

- Provide source of patient tissue, blood, and body fluid samples for ongoing diagnostic,
prognostic, or immune-monitoring studies.

- Support and enhance translational, clinical and basic research for Lineberger
Comprehensive Cancer Center (LCCC) members (and non-members who have an LCCC member as
sponsor and collaborator) with IRB-approved studies.

- Maintain responsible and appropriate policies and procedures that ensure good patient
care and responsible conduct of research.

- Address medical and legal issues, and protect participant and patient privacy and
confidentiality.

- Provide a responsible and uniform mechanism for the integrated coordination of the
hemato-pathologist and surgeon or hematology/oncology staff, researcher, and protocol
office to obtain appropriate specimens for researchers.

- Support young investigators to obtain pilot data for grant funding.

OUTLINE: Patients undergo tissue, blood, and body fluid collection during diagnostic or
routine procedures for future correlative studies. Tissue samples may include, but are not
limited to, lymph node or non-nodal biopsies, bone marrow biopsy and/or aspirate, blood and
serum, and buccal swabs for germline DNA analysis.

DISEASE CHARACTERISTICS:

- Diagnosis of abnormal hematopoietic/lymphoid cancer, including any of the following:

- Acute myeloid leukemia

- Acute lymphoblastic leukemia

- Chronic myelogenous leukemia

- Chronic lymphoid leukemia

- Non-Hodgkin lymphoma

- Hodgkin lymphoma

- Myelodysplastic syndromes

- Myeloproliferative disorders

- Multiple myeloma

- Waldenstrom macroglobulinemia

- Aplastic anemia

- Any other diseases that generate abnormalities in either number, function, or
both of any cell type of hematolymphoid lineage

- Patients who are being evaluated at the hematology/oncology clinics of the University
of North Carolina Hospitals, at the stem cell transplant clinic, or in the hospital

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- Not specified