Phase I/II Hypofractionated Radiotherapy for Prostate Cancer

The purpose of this study is to examine the clinical feasibility of using IMRT combined with
daily pretreatment prostate localization to deliver increasingly hypofractionated treatment
courses. Progressively larger fraction sizes will be delivered in a phase I design based on
both acute and long-term tolerances to the treatment. The dose-per-fraction escalation design
utilizes schemas that maintain an isoeffective dose for late effects, while predicting that
tumor control will actually improve. The delivery of fewer, larger fractions of radiation, if
proven effective and safe, would result in significant cost saving and more efficient use of
resources.