Collagen Crosslinking With Ultraviolet-A in Asymmetric Corneas (2)



Status:Terminated
Conditions:Ocular, Dermatology
Therapuetic Areas:Dermatology / Plastic Surgery, Ophthalmology
Healthy:No
Age Range:8 - Any
Updated:10/13/2018
Start Date:December 1, 2009
End Date:April 30, 2017

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Collagen Crosslinking With Ultraviolet-A in Asymmetric Corneas

To evaluate the efficacy of ultraviolet-A (UVA)-induced cross-linking of corneal collagen
(CXL) as a method to increase the biomechanical and biochemical stability of the cornea by
inducing additional cross-links within or between collagen fibers using UVA light and the
photo- mediator riboflavin. The purpose of this study is to generate data for presentation at
medical meetings and for peer-review publication


Inclusion Criteria:

- 8 years of age or older

- Diagnosis of keratoconus, post-LASIK ectasia, or pellucid marginal degeneration or
forme fruste pellucid marginal degeneration.

- Diagnosis of FFKC

- History of Radial Keratotomy with fluctuating vision.

- Ability to provide written informed consent

- Likely to complete all study visits

- Minimum corneal thickness of at least 300 measured by ultrasound or Pentacam

Exclusion Criteria:

- Severe corneal scarring that markedly affects vision

- Contraindications to any study medications or their components

- Pregnancy or breast feeding

- Active Herpes Corneal Disease
We found this trial at
5
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Littleton, CO
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Bloomington, Minnesota 55431
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mi
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Bloomington, MN
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Dallas, Texas 75231
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mi
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Dallas, TX
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Hoffman Estates, Illinois
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mi
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Hoffman Estates, IL
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San Diego, California 92121
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mi
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San Diego, CA
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