Influenza Vaccine in Lung Transplant Patients

Therapuetic Areas:Immunology / Infectious Diseases
Age Range:18 - Any
Start Date:December 2004
Contact:Mary S Hayney, PharmD

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Research Question: How do antibody and T cell responses following influenza vaccine compare
among lung transplant patients, patients waiting for lung transplantation and healthy

Experimental Design: This interventional parallel group study will compare influenza
vaccine induced immune responses in three groups: lung transplant patients, individuals
waiting for lung transplantation and healthy individuals.

Current and Future Research Activities: Blood will be drawn for these measures of vaccine
induced antibody response before and 2 to 4 weeks after immunization. Another blood draw
will be obtained from up to 30 individuals from among the three groups for measures of T
cell response to immunization. The third blood draw will be done during months 1 to 5
following influenza immunization. Genetic material (DNA) will be obtained from cells in
the blood to look for genetic markers that may be associated with influenza vaccine
response. Blood draws and immunization for the healthy participants will be done at the
General Clinical Research Center (GCRC) or in the Clinical Research Facility in Rennebohm
Hall. The blood draws for the pre-transplant and post-transplant patients will be
coordinated with clinically indicated laboratory tests in order to avoid additional
venipunctures. Influenza immunization is part of the routine clinical care of patients with
lung disease, and only the immune response data will be considered part of the research

Inclusion Criteria:

- Receiving care pre- or post-lung transplant at University of Wisconsin Hospital

- Healthy adult

Exclusion Criteria:

- Allergy to eggs

- Moderate to severe febrile illness

- Active treatment for acute rejection

- Received season's influenza vaccine prior to enrollment
We found this trial at
Madison, Wisconsin 53792
(608) 263-2400
University of Wisconsin In achievement and prestige, the University of Wisconsin–Madison has long been recognized...
Madison, WI
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