Enteral Glutamine in Neurologically-injured Patients



Status:Completed
Conditions:Hospital, Neurology
Therapuetic Areas:Neurology, Other
Healthy:No
Age Range:18 - 75
Updated:4/21/2016
Start Date:January 2003
End Date:January 2008

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Trial Summary
Trial Overview
Inclusion Criteria

Randomized, Placebo-controlled Clinical Trial of Enteral Glutamine Supplementation in Neurologically-injured Patients

Nutrition is an important part of the recovery process after having a head injury so that
subjects can gain strength and fight off infection. Liquid nutrition formulas are often
given to patients through a tube that has been placed into the intestines for feeding when
they are unable to eat on their own. Some reports suggest that nutrition with extra amounts
of the amino acid called glutamine may decrease infections and hospital stay in severely
injured patients.The purpose of this study is to evaluate if giving extra amounts of an
amino acid called glutamine with liquid nutrition formulas will decrease the risk of
infection and length of stay in the intensive care unit after having a head injury.


Inclusion Criteria:

- Males

- Nonpregnant females

- Aged 18-75 years old

- Glasgow Coma Scores of 3-12

- Injury Severity Scores greater than or equal to 20

- Requiring enteral nutrition for a minimum of 5 days

Exclusion Criteria:

- Documented hepatic dysfunction

- Acute renal failure (creatinine clearance < 15 mL/min)

- Gastrointestinal malabsorptive disorder

- Infection at time of admission
We found this trial at
1
site
University of Wisconsin
Madison, Wisconsin 53792
(608) 263-2400
University of Wisconsin In achievement and prestige, the University of Wisconsin–Madison has long been recognized...
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Madison, WI
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