Lifestyle Intervention Trial in Obese Elderly

Status:Active, not recruiting
Conditions:Obesity Weight Loss
Therapuetic Areas:Endocrinology
Age Range:65 - 85
Start Date:February 2010
End Date:April 2017

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Exercise Interventions During Voluntary Weight Loss in Obese Older Adults

Obesity causes frailty in obese older adults by exacerbating the age-related decline in
physical function. However, appropriate management of obesity in older adults is
controversial. Weight loss without exercise could worsen frailty by accelerating the usual
age-related decline in muscle and bone mass that leads to sarcopenia and osteopenia,
respectively. Because of the important problem of frailty in obese older adults, it is
important to determine the most efficacious approach in reducing, or even reversing frailty
in this population. The primary objective of this proposal is to evaluate which distinct
type of physical exercise (resistance, aerobic, or combined resistance + aerobic) is most
efficacious in preventing the weight-loss-induced reduction in muscle and bone mass and
reversing frailty in obese older adults.

Inclusion Criteria:

- 65-85 years old

- Obese men and women (BMI > or equal to 30 kg/m2)

- Stable weight (±2 kg) during the last 6 mos.

- Must be sedentary (regular exercise <1 h/wk or <2 x/wk for the last 6 mos.)

- Be judged, during the initial screening, to be well motivated and reliable

Exclusion Criteria:

- Any major chronic diseases

- Any condition or unstable diseases that would interfere with exercise or dietary
restriction, in which exercise or dietary restriction are contraindicated, or that
would interfere with interpretation of results that include but are not limited to:

- Cardiopulmonary disease (e.g., recent MI, unstable angina, stroke etc.)

- Severe orthopedic/musculoskeletal or neuromuscular impairments that would
contraindicate participation in exercise

- Visual or hearing impairments that interfere with following directions

- Diagnosis of dementia

- History of malignancy during the past 5 yr

- Recent use of bone acting drugs (e.g. use of estrogen, or androgen containing
compound, raloxifene, calcitonin, parathyroid hormone during the past year or
biphosphonates during the last two years)

- Individuals on insulin or with a fasting blood glucose of > 140mg/dl, and/or a 2 hour
post-glucose of >250 mg/dl

- BMD t-scores of <-2.3 of the lumbar spine and proximal femur

- serum creatinine >2.0 mg/dl

- No commitments, life situations or conditions that would interfere with their
participation in the study
We found this trial at
Albuquerque, NM
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1200 Moursund Street
Houston, Texas 77030
(713) 798-4951
Baylor College of Medicine Baylor College of Medicine in Houston, the only private medical school...
Houston, TX
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