The Effects of Hydrocortisone in Endotoxemia in Normal Volunteers
| Status: | Archived |
|---|---|
| Conditions: | Infectious Disease |
| Therapuetic Areas: | Immunology / Infectious Diseases |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | February 2010 |
| End Date: | December 2015 |
Corticosteroids are substances produced by the adrenal gland to help the body fight against
infection or injury. Hydrocortisone is a man-made form of this substance. Endotoxin is a
man-made substance, which causes the body to "mimic" sickness(fever,chills,and achiness)for
a few hours. This study is designed to give hydrocortisone before and after Endotoxin to
determine if this medication can prevent or relieve any of the symptoms caused by the
Endotoxin.
The body's immune response to injury otr infection is very complex. Immune cell activity,
the release of specific mediators (such as proteins), genetics (Deoxyribonucleic acid or
DNA) and/or the body's "instructions" for making proteins (Ribonucleic Acid or RNA) may
effect the body's clinical response to a stress such as an infection.Hydrocortisone is a
substance produced by the body (in the adrenal gland)in response to stress such as infection
or injury. Endotoxin is a man- made substance, which causes the body to "mimic" sickness
(fever, chills, and achiness) for a few hours. This study is designed to give hydrocortisone
before and/or after endotoxin to determine if this medication can prevent or relieve any of
the symptoms caused by endotoxin.In addition, this study may determine whether any of the
above(proteins,DNA,RNA,etc.) correlate with or affect the body's response to hydrocortisone
and/or endotoxin. This will enable the investigator to better understand whether treatment
with this substance can alter the body's immune response.
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