Both Exercise and Adenosine Stress Testing



Status:Archived
Conditions:Peripheral Vascular Disease, Cardiology
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:Any
Updated:7/1/2011

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A Pilot Study Examining the Value of Combined Exercise and Adenosine Stress Myocardial Perfusion Imaging as Compared With Adenosine Testing Alone for the Evaluation of Women at Intermediate or High Likelihood for Coronary Artery Disease


The purpose of this study is to compare the 2-year cardiac outcomes for women with limited
exercise capability based on the resuls of either pharmacological stress myocardial
perfusion imaging or a combined protocol that incorporates both exercise and pharmacological
stress. The goal of the study is to compare these two methods for patient tolerability,
safety and prognostic value


Coronary artery disease remains the leading cause of morbidity and mortality in women
accounting for more than 250,000 deaths per year. Despite the high prevalence in ischemic
heart disease in women, most clinical trials have focused on male cohorts. The optimal
non-invasive test for evaluation of ischemic heart disease in women is unknown. A number of
different modalities have been employed including exercise ECG stress testing, 2-dimensional
stress echocardiography, SPECT myocardial perfusion imaging, and electron beam computerized
tomography.

The cohort of women for whom to perform testing upon is also ill-defined. Myocardial
perfusion imaging, in conjunction with pharmacologic stress testing, has also been shown to
be effective in the diagnosis of women with known or suspected coronary artery disease as
well as in for risk stratification. Recently, pharmacologic stress has been combined with
low-level exercise, enhancing test tolerability and SPECT perfusion image quality.
Furthermore, the use of a combined adenosine and exercise protocol may detect greater
amounts of ischemia with perfusion imaging that with an exercise test alone. Therefore, in
women who may be unable to perform maximal exercise, this combined pharmacologic and
exercise imaging protocol may possess a significant advantage over adenosine stress testing
alone.

The aim of this study is to compare safety and symptoms associated with these two methods of
stress testing. The current study also seeks to establish the optimal method for detection
of coronary artery disease in women who have a limited capacity for exercise (DASI score ≤5
METS), also well as examine the prognostic value of each method of testing by comparing the
two-year event rates for women who undergo adenosine SPECT imaging or SPECT imaging using
adenosine with adjunctive exercise.


We found this trial at
18
sites
Boise, Idaho 83704
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Jacksonville, Florida 32216
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Jacksonville, FL
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1361 13th Ave S # 270
Jacksonville Beach, Florida 32250
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Jacksonville Beach, FL
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300 Community Drive
Manhasset, New York 11030
(516) 562-0100
North Shore University Hospital North Shore-LIJ Health System includes 16 award-winning hospitals and nearly 400...
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800 West 5th Avenue
Spokane, Washington 99210
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Spokane, WA
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Albany, New York 12212
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Albany, NY
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Atlanta, Georgia 30309
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Atlanta, GA
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Auburn, Maine 04210
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Auburn, ME
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Bannockburn, Illinois 60015
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Bannockburn, IL
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Charleston, South Carolina 29466
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Charleston, SC
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Des Moines, Iowa 50314
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Des Moines, IA
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Newark, Delaware 19713
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Newark, DE
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Philadelphia, Pennsylvania 19148
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Philadelphia, PA
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Roseville, California 95661
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Roseville, CA
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Sacramento, California 95825
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Sacramento, CA
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Salem, OR
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Scarborough, Maine 04074
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Scarborough, ME
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Tucson, Arizona 85715
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Tucson, AZ
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