Exercise for Stable Myasthenia Gravis
| Status: | Recruiting |
|---|---|
| Conditions: | Neurology |
| Therapuetic Areas: | Neurology |
| Healthy: | No |
| Age Range: | 18 - 70 |
| Updated: | 4/2/2016 |
| Start Date: | January 2010 |
| End Date: | December 2020 |
| Contact: | Charlene Hafer-Macko, MD |
| Email: | cmacko@grecc.umaryland.edu |
| Phone: | 410-328-3100 |
Multi-modal Exercise Program for Chronic Stable Myasthenia Gravis
Generalized fatigue in myasthenia gravis results in physical deconditioning that reduces
fitness and increases risk of obesity, hypertension, elevated cholesterol and type 2
diabetes. This study will examine how active and fit are 30 individuals with chronic,
generalized myasthenic subjects. This study will also determine whether a 3 month home
exercise program with aerobic, resistive, and pulmonary training can improve physical
activity, strength, fitness, lung function and reduce cardiovascular disease risk.
fitness and increases risk of obesity, hypertension, elevated cholesterol and type 2
diabetes. This study will examine how active and fit are 30 individuals with chronic,
generalized myasthenic subjects. This study will also determine whether a 3 month home
exercise program with aerobic, resistive, and pulmonary training can improve physical
activity, strength, fitness, lung function and reduce cardiovascular disease risk.
Generalized fatigue in myasthenia gravis results in a sedentary lifestyle and profound
physical deconditioning, leading to reduced fitness and increased risk of obesity,
hypertension, dyslipidemia, and type 2 diabetes. This study will characterize the activity
and fitness levels and cardiovascular disease risk profile in 30 chronic, generalized
myasthenic subjects. Hypotheses are that a) subjects with myasthenia gravis are physically
inactive with reduced fitness level and high incidence of obesity and poor cardiovascular
disease risk profile, and b) a 3 month multi-modal home exercise program that includes
aerobic, resistive, and pulmonary training components will improve physical activity,
strength, fitness, dyspnea, body composition and reduce cardiovascular disease risk.
Specific aims are to a) define the baseline physical activity and fitness levels and
prevalence of insulin resistance and dyslipidemia in stable sedentary myasthenic subjects,
b) determine whether a 3 month moderate intensity home exercise program is safe and feasible
in deconditioned, stable myasthenic subjects and c) whether a 3 month comprehensive home
exercise program can enhance fitness, strength, and lung function to improve physical
activity and reduce cardiovascular disease risk.
physical deconditioning, leading to reduced fitness and increased risk of obesity,
hypertension, dyslipidemia, and type 2 diabetes. This study will characterize the activity
and fitness levels and cardiovascular disease risk profile in 30 chronic, generalized
myasthenic subjects. Hypotheses are that a) subjects with myasthenia gravis are physically
inactive with reduced fitness level and high incidence of obesity and poor cardiovascular
disease risk profile, and b) a 3 month multi-modal home exercise program that includes
aerobic, resistive, and pulmonary training components will improve physical activity,
strength, fitness, dyspnea, body composition and reduce cardiovascular disease risk.
Specific aims are to a) define the baseline physical activity and fitness levels and
prevalence of insulin resistance and dyslipidemia in stable sedentary myasthenic subjects,
b) determine whether a 3 month moderate intensity home exercise program is safe and feasible
in deconditioned, stable myasthenic subjects and c) whether a 3 month comprehensive home
exercise program can enhance fitness, strength, and lung function to improve physical
activity and reduce cardiovascular disease risk.
Inclusion Criteria:
- stable generalized myasthenia gravis
- adults age 18-70
Exclusion Criteria:
- already performing regular exercise
- unstable angina
- recent (<3 month) myocardial infarction, stroke, hospitalization for major illness or
major surgery
- chronic pain or orthopedic condition restricting exercise
- active cancer, excluding basal cell cancer
- anemia (HCT <30)
- pregnancy
- myasthenia gravis exacerbation in past 3 months
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