Pilot Study of Raltegravir Switch to Resolve Tenofovir Induced Proteinuria



Status:Archived
Conditions:HIV / AIDS, Endocrine, Nephrology
Therapuetic Areas:Endocrinology, Immunology / Infectious Diseases, Nephrology / Urology
Healthy:No
Age Range:Any
Updated:7/1/2011
Start Date:January 2010
End Date:October 2010

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A Pilot Study to Evaluate the Effectiveness of a Tenofovir Raltegravir Switch in Resolving Tenofovir Induced Proteinuria in HIV Infected Individuals With Undetectable HIV Viral Loads


The study is designed to evaluate the proportion of patients with tenofovir induced
proteinuria that will resolve their proteinuria when the tenofovir containing
nucleoside/nucleotide backbone is switched to a raltegravir backbone. Common HIV treatment
regimens contain nucleoside/nucleotide combinations that may have long-term side effects
including nephrotoxicity. Switching these backbones out for an integrase inhibitor based
regimen has not been systematically evaluated.

Hypothesis: Proteinuria developing during treatment with tenofovir improves or resolves when
tenofovir is switched out with raltegravir. Switching to a nuc- sparing regimen, containing
raltegravir and a boosted protease inhibitor in patients without preexisting protease
inhibitor mutations is safe and does not lead to virologic failure



We found this trial at
2
sites
San Francisco, California 94115
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San Francisco, CA
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Long Beach, California 90813
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Long Beach, CA
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