Effect of Continuous Positive Airway Pressure (CPAP) and Cardiopulmonary Exercise Testing(CPET) in Patient With Obstructive Sleep Apnea (OSA) and Chronic Obstructive Pulmonary Disease (COPD)



Status:Recruiting
Conditions:Chronic Obstructive Pulmonary Disease, Insomnia Sleep Studies, Pulmonary
Therapuetic Areas:Psychiatry / Psychology, Pulmonary / Respiratory Diseases
Healthy:No
Age Range:18 - Any
Updated:5/5/2014
Start Date:June 2009
End Date:December 2016
Contact:Gary Kinasewitz, MD
Email:gary-kinasewitz@ouhsc.edu
Phone:405-271-6173

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Trial Summary
Trial Overview
Inclusion Criteria

Effect of Nasal CPAP on Cardiopulmonary Exercise Testing in Patients With Overlap Syndrome

Nasal CPAP will improve cardiopulmonary exercise test (CPET) performance in patients with
overlap syndrome(COPD and OSA). Nasal CPAP is proven to improve cardiopulmonary exercise
testing in patients with OSA. The investigators hypothesis is that patients with overlap
syndrome will have a greater improvement in their cardiopulmonary exercise testing besides a
possible improvement in their lung function test and airway resistance.

Patients will be included if they have overlap syndrome. Patients will undergo a spirometry
and CPET before being started on CPAP. Those tests will be repeated after 8-12 weeks of CPAP
use. Patients will be excluded if they have any contraindication to mild exercise or they
can't perform an exercise test due to limited mobility.

Inclusion Criteria:

- Obstructive sleep apnea (OSA)

- COPD

Exclusion Criteria:

- Inability to perform exercise test due to musculoskeletal limitation

- Cardiac condition preventing patient from mild exercise

- Continuous oxygen supplement
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OU Medical Center
Oklahoma City, Oklahoma 73104
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VA Medical Center
Oklahoma City, Oklahoma 73104
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