Safety and Immunologic Effect of Low Dose Versus High Dose Vitamin D3 in Multiple Sclerosis



Status:Recruiting
Conditions:Other Indications, Neurology, Gastrointestinal, Multiple Sclerosis
Therapuetic Areas:Gastroenterology, Neurology, Other
Healthy:No
Age Range:Any
Updated:2/4/2013
Start Date:March 2010
Contact:Christopher Eckstein, MD
Email:eckstein@jhmi.edu
Phone:(410) 502-1937

Use our guide to learn which trials are right for you!

A Pilot Study to Assess the Relative Safety and Immunology Effects of Low Dose Versus High Dose Cholecalciferol Supplementation in Patients With Multiple Sclerosis


The purpose of this study is to determine the safety and the immunologic effects of
supplementation with low-dose and high-dose cholecalciferol (vitamin D3) in patients with
multiple sclerosis.


Inclusion Criteria:

- Between ages of 18-55 years (inclusive)

- Serum 25(OH) vitamin D levels between 20-50 ng/mL and a candidate for vitamin D
supplementation

- Patients with or without immunomodulatory therapy for RRMS

- Diagnosis of multiple sclerosis

Exclusion Criteria:

- Serum 25(OH) vitamin D deficient level < 20 ng/mL

- High dose vitamin D supplementation in the past 3 months

- Pregnancy

- History of tuberculosis, hyperparathyroidism, sarcoidosis or kidney stones

- Baseline serum creatinine above 1.5

- Hypersensitivity to vitamin D preparations

- Milk allergy

- Unable to consent
We found this trial at
1
site
3400 N Charles St
Baltimore, Maryland 21205
410-516-8000
Johns Hopkins University The Johns Hopkins University opened in 1876, with the inauguration of its...
?
mi
from
Baltimore, MD
Click here to add this to my saved trials