Dynamic Magnetic Resonance Imaging (MRI) for Lung Tumor Motion and Lung Function (GCC 0943)
| Status: | Completed |
|---|---|
| Conditions: | Lung Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | November 2009 |
| End Date: | October 2015 |
Dynamic MRI for Lung Tumor Motion and Lung Function
Radiation treatment for each patient with cancer is designed based on CT scans. We know that
tumors in the chest and abdomen move when you breathe. Because of this, there can be
differences between planned treatment and the treatment actually delivered to the body.
Usually with radiation a safety margin is added to ensure that radiation hits the entire
tumor. This can damage healthy parts of the body because the exact location of the tumor is
unknown.
Magnetic resonance imaging (MRI) is a painless and safe diagnostic procedure that uses a
powerful magnet and radio waves to produce detailed images of the body's organs and
structures, without the use of X-rays or other radiation.
The research doctors are studying to see if the position of a tumor can be tracked using MRI
scans and tracking sensors placed on the skin. MRI scans and the tracking system used to
calculate the location and position of the tumor are both FDA approved technologies.
The research doctors will also use the MRI scans to evaluate any changes in your lung
function during and following your radiation treatments.
In this study the participant will undergo a series of MRI scans with and without contrast
dye.
This study is being funded through grants from the National Institutes of Health (NIH).
tumors in the chest and abdomen move when you breathe. Because of this, there can be
differences between planned treatment and the treatment actually delivered to the body.
Usually with radiation a safety margin is added to ensure that radiation hits the entire
tumor. This can damage healthy parts of the body because the exact location of the tumor is
unknown.
Magnetic resonance imaging (MRI) is a painless and safe diagnostic procedure that uses a
powerful magnet and radio waves to produce detailed images of the body's organs and
structures, without the use of X-rays or other radiation.
The research doctors are studying to see if the position of a tumor can be tracked using MRI
scans and tracking sensors placed on the skin. MRI scans and the tracking system used to
calculate the location and position of the tumor are both FDA approved technologies.
The research doctors will also use the MRI scans to evaluate any changes in your lung
function during and following your radiation treatments.
In this study the participant will undergo a series of MRI scans with and without contrast
dye.
This study is being funded through grants from the National Institutes of Health (NIH).
In this protocol, we seek to assess whether tumor motion can be inferred using dynamic MRI
and external surrogates. We propose to (1) investigate the feasibility of tracking the
real-time tumor position using dynamic MRI and inferring tumor position using external
surrogates placed on the skin of the subject and (2) determine lung function during and
following radiation by assessing lung perfusion maps obtained via dynamic MRI with dose maps
in order to determine image-based biomarkers for lung toxicity following radiation therapy.
and external surrogates. We propose to (1) investigate the feasibility of tracking the
real-time tumor position using dynamic MRI and inferring tumor position using external
surrogates placed on the skin of the subject and (2) determine lung function during and
following radiation by assessing lung perfusion maps obtained via dynamic MRI with dose maps
in order to determine image-based biomarkers for lung toxicity following radiation therapy.
Inclusion Criteria:
- Patients 18 years old or older
- Patients must be undergoing radiation therapy with or without chemotherapy for
thoracic and/or abdominal cancers.
Exclusion Criteria:
- Pregnant or breast-feeding women are excluded. Negative serum or urine pregnancy test
prior to study entry is required. Once on the protocol, the patient will be advised
and expected to implement an accepted and effective method of contraception such as
oral contraceptives (birthcontrol pill), intrauterine devices (IUDs), contraceptive
implants under skin or contraceptive injections and condoms with foam.
- Patients with kidney disease of any severity or on hemodialysis.
- Patients who have metallic dental fillings or other metallic implants.
- Patients with known allergies to gadolinium-based contrast agents.
- Patients who have difficulty lying flat on their back for extended periods of time
will be excluded
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