Clinical Phenotyping Resource and Biobank Core of the Michigan O'Brien Renal Center



Status:Recruiting
Conditions:Renal Impairment / Chronic Kidney Disease
Therapuetic Areas:Nephrology / Urology
Healthy:No
Age Range:Any
Updated:8/4/2018
Start Date:January 2009
End Date:July 2022
Contact:Chrysta Lienczewski
Email:boridley@med.umich.edu
Phone:734-615-5021

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Chronic kidney disease (CKD) affects approximately 26 million Americans and
disproportionately manifests in specific race and ethnic groups. Patients burdened with CKD
have significant morbidity and reduced life expectancy. In addition to excessive suffering
and lost productivity, the cost of managing this epidemic has reached $40 billion annually.
The recognition that CKD is a major public health problem is reflected in the fourteen
objectives outlined in Healthy People 2020 to begin to address the disease burden.
Advancement in approaches to halt CKD progression has been slow despite growing global
awareness of disease burden.

This O'Brien Kidney Research Core will create opportunities for novel insights through
characterization of tissue profiles that will define new disease markers and molecular
pathways and will be available to all kidney investigators on the www. It will thereby
fundamentally alter the starting point for research into prevention of progression of these
kidney diseases. C-PROBE is an essential element of the center grant and presents a
biomedical resource core consisting of: (1) clinical phenotyping (that is, systematic
identification of observable physical and biomedical characteristics) of kidney disease
patients including the accurate measurement of kidney function; and (2) a specimen BioBank
which will store blood, urine and kidney tissue samples. A key component of C-PROBE is
therefore that it contains a proven mechanism to collect samples from high risk groups
including minorities, at the institutions of University of Michigan Health System, St. John
Hospital, Wayne State University in Michigan, John H. Stroger Hospital in Illinois, Temple
University Health System in Pennsylvania, and Levine Children's Hospital in North Carolina.
This mechanism will feed the other Cores and provide biomedical investigators with approved
projects the access to a dynamic pool of well characterized high risk kidney disease patients
and their biological specimens to conduct high caliber translational research.


Inclusion Criteria:

- persons of any age who have chronic kidney disease (abnormally high protein in urine
or reduced kidney function determined by blood tests)

- a small number of people without chronic kidney disease

Exclusion Criteria:

- people on hemodialysis or peritoneal dialysis

- people who have had a kidney transplant

- people unable or unwilling to provide consent

- women who are pregnant or nursing

- adults who have polycystic kidney disease

- institutionalized persons

- people currently participating in a blinded interventional clinical trial
We found this trial at
6
sites
1500 E Medical Center Dr
Ann Arbor, Michigan 48109
(734) 936-4000
Principal Investigator: Subramaniam Pennathur, MBBS
Phone: 734-615-8304
University of Michigan Health System The University of Michigan is home to one of the...
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5050 Anthony Wayne Dr
Detroit, Michigan 48201
(313) 577-2424
Principal Investigator: Zeenat Bhat, MD
Phone: 313-745-2378
Wayne State University Founded in 1868, Wayne State University is a nationally recognized metropolitan research...
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Detroit, MI
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Charlotte, North Carolina 28204
Principal Investigator: Susan Massengill, MD
Phone: 704-347-2273
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Charlotte, NC
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Chicago, Illinois 60612
Principal Investigator: Kalyani Perumal, MD
Phone: 312-864-4614
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Chicago, IL
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Detroit, Michigan 48236
Principal Investigator: Keith Bellovich, DO
Phone: 313-886-8787
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Detroit, MI
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1801 N Broad St
Philadelphia, Pennsylvania 19122
(215) 204-7000
Principal Investigator: Crystal A Gadegbeku, MD
Phone: 201-707-4712
Temple University Temple University is many things to many people. A place to pursue life's...
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Philadelphia, PA
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