Efficacy of Celecoxib Vs Placebo to Prevent Pain in a Paced Walk
| Status: | Completed |
|---|---|
| Conditions: | Arthritis, Osteoarthritis (OA) |
| Therapuetic Areas: | Rheumatology |
| Healthy: | No |
| Age Range: | 45 - 85 |
| Updated: | 4/2/2016 |
| Start Date: | June 2004 |
| End Date: | September 2005 |
| Contact: | Michele M Hooper, MD, MS |
| Email: | michele.hooper@uhhs.com |
| Phone: | (216) 591-1443 |
A Double-Blind, Placebo-Controlled, Crossover Pilot Study of the Efficacy of Celecoxib 200 Mg Qd in Relieving Pain and Walking Dysfunction in Osteoarthritis of the Knee
A paced 20-minute walk is a reproducible model for acute pain in knee osteoarthritis
This is a randomizd, placbo-controlled, crossover trial comparing a single dose of celecoxib
to placebo measuring the time to onset of acute pain in a paced 20-minute walk.
40 subjects will be enrolled
to placebo measuring the time to onset of acute pain in a paced 20-minute walk.
40 subjects will be enrolled
Inclusion Criteria:
Knee osteoarthritis by ACR clinical criteria Pain of at least 40 mm by VAS at baseline
Exclusion Criteria:
Non-pregant, non-lactating Able to stop active arthritis medication for washout
Cardiovascular risk factors Abnormal EKG -
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