Study Comparing Whole Breast Radiotherapy With a Daily Versus a Weekly Tumor
| Status: | Archived |
|---|---|
| Conditions: | Breast Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | March 2009 |
| End Date: | March 2022 |
Phase III Study Comparing Whole Breast Radiotherapy With a Daily Versus a Weekly Tumor
All patients (with Stages 0-II breast cancer) will receive an accelerated three week regimen
of prone whole breast radiotherapy. The study intends to test the hypothesis that a weekly
boost to the tumor bed, delivered on Friday, before the weekend break, is as well tolerated
as the daily boost during accelerated prone radiotherapy.
Arm 1 is a concomitant boost protocol over three weeks which has previously been evaluated
in over 500 patients (NYU 03-30 and NYU 05-181) and has shown excellent tolerance, and
results. Arm 2 evaluates a Weekend Boost Dose (WBD) regimen which may have a
radiobiological advantage by counteracting tumor repopulation which can occur over the
weekend break. At the time of registration in the study, patients will be randomized to
either treatment arm and stratified according to pre or post-menopausal status and on
previous chemotherapy received or not.
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New York University Langone Medical Center NYU NYU Langone Medical Center, a world-class, patient-centered, integrated,...
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