Plerixafor in Treating Patients With Multiple Myeloma Previously Treated With Lenalidomide and Planning to Undergo Autologous Stem Cell Transplant



Status:Archived
Conditions:Blood Cancer, Hematology
Therapuetic Areas:Hematology, Oncology
Healthy:No
Age Range:Any
Updated:7/1/2011
Start Date:December 2009

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Phase II Trial of Intravenously Administered AMD3100 (Plerixafor) for Stem Cell Mobilization in Patients With Multiple Myeloma Undergoing Autologous Stem Cell Transplantation Following a Lenalidomide Based Initial Therapy


Rationale: Giving colony-stimulating factors, such as G-CSF and plerixafor helps stem cells
move from the patient's bone marrow to the blood so they can be collected and stored.
Purpose: This phase II trial is studying how well plerixafor works in patients with multiple
myeloma previously treated with lenalidomide and planning to undergo autologous stem cell
transplant.


Primary Objective: I. To determine the proportion of patients reaching a stem cell yield of
3 million CD34 cells/kg by second day of apheresis with intravenously administered AMD3100
among patients receiving primary therapy for myeloma with lenalidomide. Secondary
Objectives: I. Safety and tolerability of intravenously administered AMD3100. II. Rate of
failure to mobilize. Outline: Patients receive plerixafor IV on days 5-8 and filgrastim
subcutaneously on days 1-8 in the absence of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed at 30 days.


We found this trial at
2
sites
5777 E Mayo Blvd
Scottsdale, Arizona 85259
(480) 515-6296
Mayo Clinic Scottsdale Mayo Clinic Arizona was the second Mayo practice to be established outside...
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200 First Street SW
Rochester, Minnesota 55905
507-284-2511
Mayo Clinic Rochester Mayo Clinic is a nonprofit worldwide leader in medical care, research and...
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Rochester, MN
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