Evaluation of the Genetics of Bipolar Disorder

Bipolar affective disorder is a severe, heritable condition affecting about one percent of

the population. The mode of inheritance is poorly understood and probably involves multiple
loci of small to moderate effect. In this project, we use genetic mapping and sequencing
methods to identify genetic markers and variations that contribute to the risk of bipolar
disorder. Individuals diagnosed with bipolar disorder are studied, along with their
relatives. Phenotypic information obtained from clinical interviews and family history is
correlated with genotypic information obtained from genetic marker and sequencing methods.
The goal is to identify genes involved in bipolar disorder and related conditions so that
better methods of diagnosis, treatment, and prevention can be developed.

- INCLUSION CRITERIA:

Age > 18 yr

Able to provide informed consent

Bipolar disorder or related conditions not attributable to substance abuse, neurological
disease; or a 1st or 2nd degree relative of an enrolled participant. Related conditions are
defined as those found more often among relatives of people with bipolar disorder or which
have been shown to be genetically correlated with bipolar disorder through molecular
genetic studies. These include major depression, schizophrenia, panic disorder, and
attention deficit hyperactivity disorder.

Able to safely provide a blood or saliva sample

EXCLUSION CRITERIA:

Active alcohol or substance abuse.

NIMH employees/staff and their immediate family members will be excluded from the study per
NIMH policy.