Microparticles in Pediatric Inflammatory Disease
| Status: | Archived |
|---|---|
| Conditions: | Colitis, Irritable Bowel Syndrome (IBS), Gastrointestinal, Crohns Disease |
| Therapuetic Areas: | Gastroenterology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | August 2009 |
| End Date: | August 2010 |
Microparticles in Pediatric Inflammatory Bowel Disease
The purpose of this study is to provide data correlating levels of microparticles that
circulate in the blood and disease activity in children with inflammatory bowel disease
(IBD). The hypothesis is that circulating microparticles will be higher in children with
active IBD, show inflammatory activity, and will be low in patients in remission as well as
in healthy controls.
Once the response of microparticles to inflammation is defined in this patient population,
the microparticles can be used as biomarkers of disease activity and could potentially use
microparticles as targets of therapeutic agents.
This cross sectional study will enroll 15 Crohn's patients (5 inactive, 5 mild, 5
moderate-severe disease based on the pediatric Crohn's disease activity index), 15
Ulcerative Colitis patients (5 inactive, 5 mild, 5 moderate-severe disease based on the
pediatric ulcerative colitis activity index), and 10 healthy controls.
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