WISE ARIC: Retinal Photography in Women With Chest Pain
| Status: | Completed |
|---|---|
| Conditions: | Angina |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - 75 |
| Updated: | 4/21/2016 |
| Start Date: | June 2003 |
| End Date: | September 2014 |
Retinal Photography in Women With Chest Pain: A WISE/ARIC Collaboration
The purposes of this study are:
- To correlate the severity of retinal arteriolar narrowing and other microvascular
changes, as determined from retinal photographs and video imaging, to measures of
coronary microvascular function in women evaluated for chest pain.
- To evaluate measures of vascular compliance with applanation tonometry and
photoplethysmography using a nasal alar probe.
- To correlate the severity of retinal arteriolar narrowing and other microvascular
changes, as determined from retinal photographs and video imaging, to measures of
coronary microvascular function in women evaluated for chest pain.
- To evaluate measures of vascular compliance with applanation tonometry and
photoplethysmography using a nasal alar probe.
Women who meet study eligibility criteria and provide written informed consent will have a
baseline physical exam, including measurements of heart rate, blood pressure, weight.
Medical history will be updated, specifically cardiovascular events (hospitalizations,
procedures) since last contact and current medications. Patients will be scheduled for
retinal photography. Those who are currently being screened and qualify for EWISE or other
ancillary studies will have retinal photography scheduled as close to the index CFR as
possible and prior to receiving randomized therapy.
The retinal photography will follow a standardized written protocol.
For the second protocol, 100 patients will be scheduled for an appointment in the Eye clinic
where they will meet the Women's Ischemic Syndrome Evaluation (WISE)/Atherosclerosis Risk in
Communities (ARIC) staff and complete the baseline information and have a brief physical
examination. They will then have provocative testing completed with retinal imaging.
baseline physical exam, including measurements of heart rate, blood pressure, weight.
Medical history will be updated, specifically cardiovascular events (hospitalizations,
procedures) since last contact and current medications. Patients will be scheduled for
retinal photography. Those who are currently being screened and qualify for EWISE or other
ancillary studies will have retinal photography scheduled as close to the index CFR as
possible and prior to receiving randomized therapy.
The retinal photography will follow a standardized written protocol.
For the second protocol, 100 patients will be scheduled for an appointment in the Eye clinic
where they will meet the Women's Ischemic Syndrome Evaluation (WISE)/Atherosclerosis Risk in
Communities (ARIC) staff and complete the baseline information and have a brief physical
examination. They will then have provocative testing completed with retinal imaging.
Inclusion Criteria:
- Women who participated in or are being screened for the WISE or EWISE or any
ancillary studies
- Willing to provide written informed consent
- Have recorded measurements of coronary flow reserve, with or without obstructive
coronary disease
Exclusion Criteria:
- Unwilling to complete study required procedures
- Contraindication to adenosine
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