A Phase 1 Study of ARRY-438162 (MEK162) in Patients With Advanced Solid Tumors Followed by Expansion Cohorts in Patients With Advanced or Metastatic Biliary Cancer or Metastatic Colorectal Cancer



Status:Archived
Conditions:Colorectal Cancer, Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:Any
Updated:7/1/2011
Start Date:August 2009

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This is a 3-part study to assess the safety, tolerability, and pharmacokinetics of
ARRY-438162 (MEK162) in patients with advanced solid tumors. The first part is an open-label
dose escalation study to establish the maximum tolerated dose of ARRY-438162 (MEK162).
Approximately 30 patients from the US will be enrolled in Part 1. (Active, Not Recruiting)

The second part, expansion at maximum tolerated dose (MTD), is designed to assess the
safety, preliminary efficacy, pharmacokinetics (PK), pharmacodynamics (PD) in patients with
advanced or metastatic biliary cancer. Approximately 25 patients from the US will be
enrolled in Part 2. (Active, Not Recruiting)

The third part, CRC expansion at MTD is designed to assess the safety, preliminary efficacy,
pharmacokinetics, pharmacodynamics in patients with metastatic colorectal cancer.
Approximately 25 patients with KRAS mutation and 15 patients with BRAF mutation will be
enrolled in the US. (Recruiting)



We found this trial at
10
sites
1500 East Medical Center Drive
Ann Arbor, Michigan 48109
800-865-1125
University of Michigan Comprehensive Cancer Center The U-M Comprehensive Cancer Center's mission is the conquest...
1932
mi
from 91732
Ann Arbor, MI
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Baltimore, Maryland 21231
410-955-6190
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins The name Johns Hopkins has become synonymous...
2302
mi
from 91732
Baltimore, MD
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1240 North Mission Road # L919
Los Angeles, California 90033
11
mi
from 91732
Los Angeles, CA
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1400 South Orange Avenue
Orlando, Florida 32806
407-648-3800
M. D. Anderson Cancer Center Welcome to UF Health Cancer Center at Orlando Health. For...
2184
mi
from 91732
Orlando, FL
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1 Brookings Drive
St. Louis, Missouri 63110
 (314) 935-5000
Washington University Washington University creates an environment to encourage and support an ethos of wide-ranging...
1569
mi
from 91732
St. Louis, MO
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13001 E. 17th Pl.
Aurora, Colorado 80045
303-724-5000
University of Colorado Cancer Center - Anschutz Cancer Pavilion The University of Colorado Denver |...
825
mi
from 91732
Aurora, CO
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Boston, Massachusetts 02130
2578
mi
from 91732
Boston, MA
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281 W. Lane Ave
Columbus, Ohio 43210
(614) 292-6446
Ohio State University The Ohio State University’s main Columbus campus is one of America’s largest...
1959
mi
from 91732
Columbus, OH
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230 25th Ave N
Nashville, Tennessee 37203
(615) 329-7274
Sarah Cannon Cancer Center People who live with cancer
1762
mi
from 91732
Nashville, TN
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1182
mi
from 91732
San Antonio, TX
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