Calorie Restriction and Changes in Body Composition, Disease, Function, and Quality of Life in Older Adults

Conditions:High Blood Pressure (Hypertension), High Cholesterol, Obesity Weight Loss, Cardiology
Therapuetic Areas:Cardiology / Vascular Diseases, Endocrinology
Age Range:65 - Any
Start Date:June 2010
Contact:Marilyn Hass

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The investigators want to determine if the benefits of weight loss outweigh the potential
risk in a group of older adults. The investigators will test the hypothesis that changes in
diet composition alone or in conjunction with weight loss will have a significant effect on
fat stores, and as a result, improve cardiometabolic risk factors and functional status in
adults 65 and older.

Inclusion Criteria:

- at least 65 years of age

- BMI 27 - 42 kg/m2 - at increased health risk (taking at least 1 medication for
hypertension, hyperlipidemia, or type 2 diabetes)

Exclusion Criteria:

- difficulties chewing or swallowing food

- digestive diseases that may affect the ability to follow a high fiber diet

- cognitive impairment

- depression

- recent weight change (+/- 10 lbs in the last 12 months)

- poorly controlled blood pressure

- history of non-skin cancer in last 5 years

- cardiovascular disease event in past 6 months or severe pulmonary disease or renal

- major liver dysfunction

- current smoker or quit less than months prior

- history of prior surgical procedures for weight control or liposuction

- use of estrogen or testosterone replacement therapy

- current use of insulin or sulfonylurea agents

- current use of corticosteroids > 5 days/month on average

- current use of medications for treatment of psychosis or manic-depressive illness

- use of weight-loss medications in previous 3 months

- dependence on others for food procurement or preparation

- ischemic changes on exercise treadmill test
We found this trial at
1720 2nd Ave S
Birmingham, Alabama 35233
(205) 934-4011 
University of Alabama at Birmingham The University of Alabama at Birmingham (UAB) traces its roots...
Birmingham, AL
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