Calorie Restriction and Changes in Body Composition, Disease, Function, and Quality of Life in Older Adults
| Status: | Recruiting |
|---|---|
| Conditions: | High Blood Pressure (Hypertension), High Cholesterol, Obesity Weight Loss, Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Endocrinology |
| Healthy: | No |
| Age Range: | 65 - Any |
| Updated: | 11/23/2013 |
| Start Date: | June 2010 |
| Contact: | Marilyn Hass |
| Email: | mhaas@uabmc.edu |
| Phone: | 205-934-7918 |
The investigators want to determine if the benefits of weight loss outweigh the potential
risk in a group of older adults. The investigators will test the hypothesis that changes in
diet composition alone or in conjunction with weight loss will have a significant effect on
fat stores, and as a result, improve cardiometabolic risk factors and functional status in
adults 65 and older.
Inclusion Criteria:
- at least 65 years of age
- BMI 27 - 42 kg/m2 - at increased health risk (taking at least 1 medication for
hypertension, hyperlipidemia, or type 2 diabetes)
Exclusion Criteria:
- difficulties chewing or swallowing food
- digestive diseases that may affect the ability to follow a high fiber diet
- cognitive impairment
- depression
- recent weight change (+/- 10 lbs in the last 12 months)
- poorly controlled blood pressure
- history of non-skin cancer in last 5 years
- cardiovascular disease event in past 6 months or severe pulmonary disease or renal
failure
- major liver dysfunction
- current smoker or quit less than months prior
- history of prior surgical procedures for weight control or liposuction
- use of estrogen or testosterone replacement therapy
- current use of insulin or sulfonylurea agents
- current use of corticosteroids > 5 days/month on average
- current use of medications for treatment of psychosis or manic-depressive illness
- use of weight-loss medications in previous 3 months
- dependence on others for food procurement or preparation
- ischemic changes on exercise treadmill test
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