Non-Treatment Study of Factors Affecting Cocaine Drug Choice
| Status: | Archived |
|---|---|
| Conditions: | Psychiatric, Pulmonary |
| Therapuetic Areas: | Psychiatry / Psychology, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | July 2009 |
| End Date: | July 2011 |
Human Laboratory Model of Cocaine Treatment: Behavioral Economic Analysis: Study 1
This research deals with behaviors that are part of drug dependence. The purpose is to study
how certain factors, including money, the amount of drug available, and the amount of work
effort, affect cocaine drug choice. Specifically, we will examine the effects of two
issues/factors. The first is how hard individuals are willing to work to obtain a drug; the
second is how much drug would individuals choose instead of money, when the amount of
probability of money is predictable or unpredictable.
Outpatient Phase: Participants will be outpatients and must come to the Jefferson Avenue
Research Program three times a week (Mon-Wed-Fri). This phase will last two weeks. At each
visit participants will be asked to provide a urine sample and to complete questionnaires
that ask about substance use.
Inpatient Phase: Participants will live on an inpatient research unit at least 2 consecutive
nights and possibly up to 20 consecutive nights. Participants cannot have visitors and will
not be allowed to leave the inpatient unit (except with a staff escort) unless they drop out
of the study. We will collect daily urine samples to make sure participants are not using
any drugs except those in the study.
Participants will take part in multiple trials (up to 11 experimental sessions) where they
will be given a standard amount of powder (identified as Drug A or Drug B) to inhale through
a straw into their nose. The powder will contain placebo (a powder containing no drug) or
different doses of cocaine. We will measure how participants are feeling using
questionnaires and we will record vital signs—including breathing rate, blood oxygen level,
heart rate, and blood pressure.
Participants will also be asked to perform a 3-hour computer task that allows them to work
for Drug A, Drug B, or money. At the end of the computer task participants will receive the
amount of drug they earned and a receipt for the amount of money they earned.
To complete the study, a minimum stay of 16 inpatient nights is required. The maximum stay
is 20 inpatient nights.
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