Magnetic Resonance Spectroscopy Studies of Cardiac Muscle Metabolism



Status:Recruiting
Conditions:Cardiology
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:18 - Any
Updated:11/7/2018
Start Date:January 1988
End Date:August 2020
Contact:Robert G. Weiss, MD
Email:rweiss@jhmi.edu
Phone:410-955-1703

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Trial Summary
Trial Overview
Inclusion Criteria

In Vivo Cardiac Metabolism in Normal, Ischemic, and Cardiomyopathic Patients During Rest and Stress

The metabolism of the heart provides the chemical energy needed to fuel ongoing normal heart
contraction. Magnetic resonance spectroscopy is a technique used in a MRI scanner that can be
used to measure and study heart metabolism directly but without blood sampling or obtaining
tissue biopsies. One of the hypotheses this study aims to investigate is whether energy
metabolism is reduced in heart failure and whether that contributes to the poor heart
function.

This study uses magnetic resonance (MR) spectroscopy to study heart metabolism and function
in normal subjects and patients with left ventricular hypertrophy, dilated cardiomyopathy,
and those with coronary artery disease.

Inclusion Criteria:

- age > 18 years

- Healthy subjects: no history of heart disease

- Dilated cardiomyopathy: history of heart failure, ejection fraction (EF) <40%

- Left ventricular hypertrophy: wall thickness >1.2cm

- Coronary artery disease: >50% coronary lesion or positive stress test

Exclusion Criteria:

- contraindication to MRI
We found this trial at
1
site
Johns Hopkins Medical Institutions
Baltimore, Maryland 21287
Phone: 443-287-3469
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mi
from
Baltimore, MD
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