Psychotherapy for Depressed Mothers of Psychiatrically Ill Children

This study will compare a psychotherapy for mothers that targets factors known to be
associated with the intergenerational transmission of psychiatric disorders to a nonspecific
psychotherapeutic control condition. It will evaluate outcomes in both children and mothers.
A modified form of interpersonal psychotherapy for depression, IPT-MOMS, specifically
addresses maternal depressive symptoms, maternal interpersonal functioning, and mother-child
communication, all factors that contribute to psychiatric illness in youth (Swartz et al.,
2006). This application proposes to recruit mother-child dyads, both of whom suffer from
psychiatric illness, randomly assign mothers to nine sessions over 3 months of either
IPT-MOMS (N=105) or brief supportive psychotherapy (BSP; N=105), and evaluate the impact of
acute maternal treatment on child and maternal outcomes at 3, 6, 9, and 12 month follow-up.

Inclusion Criteria:

Inclusion Criteria (Mothers)

1. Adult female, age 18-65

2. Biological or adoptive mother of child, age 7-18, who meets child inclusion criteria
(see below)

3. Lives with and has custody of the eligible child participant

4. Currently in an episode of major depression, as defined by the DSM-IV and documented
by the use of the Structured Clinical Interview for Axis I DSM-IV Disorders (SCID-I)

5. Score > or equal to 15 on the 25-item Hamilton Rating Scale for Depression (HRSD-25)

6. Ability and willingness to give informed, written consent

7. Willingness to give informed consent for their eligible and assenting child to
participate

Inclusion Criteria (Psychiatrically Ill Children)

1. Age 7-18

2. Currently meets criteria for at least one current depressive or anxiety disorder as
defined by the DSM-IV (American Psychiatric Association, 1994) and documented by the
Schedule for Affective Disorders and Schizophrenia for School Age Children, Present
and Lifetime version (K-SADS-PL)

3. Willingness to provide informed consent/assent

Exclusion Criteria:

Exclusion Criteria (Mothers)

1. If a mother subject IS NOT on antidepressants:

Mothers must be off all antidepressant medications for at least 14 days (30 days for
fluoxetine) prior to screening to ensure that pretreatment assessments are not
distorted by drug withdrawal or rebound effects). Mother subjects cannot start taking
antidepressant medications during the acute treatment phase. If they do start taking
antidepressant medication during the acute treatment portion of the study, their
participation in the acute phase of the study will be terminated. They will be
continued to be followed in the follow-up phase.

If a mother subject IS on antidepressants:

Mothers must be on a stable dose of an antidepressant medication (4 consecutive weeks
at the same dose) prior to signing consent. The mother subject must agree to stay on
the same antidepressant at this current dose throughout the duration of the acute
phase of the study. If a participant's dosage of an antidepressant medication is
changed or if they cease taking their antidepressant medication during the acute
treatment portion of the study, their participation in the acute phase of the study
will be terminated. They will be continued to be followed in the follow-up phase.

2. Active suicidal ideation or homicidal ideation that in the clinical opinion of the
research team as headed by the PI, would require hospitalization

3. At serious risk for child abuse or neglect which in the clinical opinion of the
research team as headed by the PI, requires intervention

4. Comorbid psychotic disorder, organic mental disorder, current (within prior six
months) substance or alcohol abuse, borderline personality disorder, antisocial
personality disorder, or history of a prior manic episode (bipolar disorder)

5. Significant medical illness that might explain depressive symptoms such as epilepsy,
autoimmune disorders, or unstable endocrine disease

6. Not fluent in English. The intervention to be tested in this study is psychotherapy.
The staff is only trained to deliver these interventions in English. Thus, all
subjects must be fluent in English.

7. Severe cognitive deficits that would preclude treatment with psychotherapy and/or
prevent completion of study questionnaires

8. Current receipt of another form of individual psychotherapy; concurrent participation
in a support group (such as Alcoholics Anonymous), couples therapy, or family therapy
will be permitted

9. Currently in an abusive relationship as determined by the domestic violence
questionnaire and/or PI's judgment

10. Unwilling or unable to comply with study requirements (i.e., complete forms, attend
scheduled evaluations)

Exclusion Criteria (Psychiatrically Ill Children)

1. Meets criteria for mental retardation, autistic disorder, schizophrenia, or current
(within prior 6 months) substance or alcohol abuse

2. Significant cognitive impairment or learning delays that would prevent completion of
study questionnaires

3. Significant chronic medical illness that might explain depressive or anxiety symptoms
such as sickle cell anemia, cystic fibrosis, or leukemia; children with moderate
medical illnesses may be included in the study if the PI determines it is of no
greater risk to the child's medical illness

4. Unwilling or unable to comply with study requirements (i.e., complete forms, attend
scheduled evaluations)