Assessment of Candidate Protein Expression in Breast Cancer Specimens



Status:Recruiting
Conditions:Breast Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:Any
Updated:4/4/2019
Start Date:April 24, 2008
End Date:December 2019
Contact:Ruth Keri, PhD
Email:ruth.keri@case.edu
Phone:216-368-3495

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Trial Summary
Trial Overview
Inclusion Criteria

Assessment of Candidate Protein Expression in Human Breast Cancer Specimens

RATIONALE: Studying the genes expressed in samples of tumor tissue from patients with cancer
may help doctors identify biomarkers related to cancer.

PURPOSE: This research study is looking at tumor tissue samples from patients who have
undergone surgery for breast cancer.

OBJECTIVES:

- To determine if candidate genes display differential expression between normal and
cancer breast tissues.

OUTLINE: Previously collected breast cancer tissue samples (paraffin embedded blocks) and
normal adjacent tissue are used for immunohistochemistry studies of expression of candidate
genes.

Inclusion Criteria:

DISEASE CHARACTERISTICS:

- Diagnosis of breast cancer

- Tissue samples available

- Samples are selected based on presence or absence of tumor receptors, (i.e.; estrogen,
progesterone, and HER2 receptors) and grouped into following 4 categories:

- Estrogen receptor (ER)-positive/progesterone receptor (PR)-positive/HER2-negative

- ER-positive/PR-positive/ HER2-positive by FISH

- ER-negative/PR-negative/HER2-positive

- ER-negative/PR-negative/HER2-negative(triple negative or basal-type cancers)

PATIENT CHARACTERISTICS:

- Menopausal status not specified

PRIOR CONCURRENT THERAPY:

- Not specified

Exclusion Criteria:

- There are no exclusion criteria in this protocol
We found this trial at
1
site
University Hospitals Cleveland Medical Center, Seidman Cancer Center, Case Comprehensive Cancer Center
Cleveland, Ohio 44106
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mi
from
Cleveland, OH
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