Functional Magnetic Resonance Imaging (fMRI) of Anosognosia in Amnestic Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD)

This is a three year fMRI study conducted at the University of Wisconsin (UW) Hospital and
the William. S. Middleton VA Hospital. This study is guided by the hypothesis that reduced
fMRI activity and connectivity cortical midline structures (i.e., medial frontal and ventral
posterior cingulate cortex) are physiologic abnormalities that relate strongly to the
compromised insight into cognitive deficits, or anosognosia, shown by a subset of
individuals with amnestic MCI (aMCI) and AD. Further, the investigators hypothesize that
these regional changes in fMRI activity are predictive of faster progression from aMCI to
AD.