Mucus Dehydration and Evolution of Chronic Obstructive Pulmonary Disease (COPD) Lung Disease
| Status: | Completed |
|---|---|
| Conditions: | Bronchitis, Chronic Obstructive Pulmonary Disease, Pulmonary |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 2/4/2013 |
| Start Date: | September 2006 |
| End Date: | August 2011 |
| Contact: | Claudia J. Salazar |
| Email: | jsalazar@med.unc.edu |
| Phone: | (919) 966-2531 |
Mucus Dehydration and Evolution of COPD Lung Disease
The purpose of this research is to understand the properties of mucus in persons with COPD,
specifically Chronic Bronchitis. The investigators hypothesize that those with Chronic
Bronchitis have dehydrated mucus, and thus have a harder time coughing it out of their
lungs. This leads to a greater vulnerability for lung infection, inflammation and airflow
obstruction. Ultimately, the investigators' goal is to understand how mucus dehydration
contributes to the progression of COPD/Chronic Bronchitis so that better therapies and
interventions can be developed for future generations.
Specific Aim I directly tests the hypothesis that mucus clearance is impaired due to mucus
dehydration. It measures 1) COPD Mucociliary and Cough Clearance 2) mucus hydration 3) the
concentrations of the dominant regulators of airway hydration and 4) the consequences of
mucus dehydration on mucus biophysical properties and bacterial infection.
Specific Aim II tests the hypothesis that COPD acute exacerbations are associated with
failures of mucus clearance. Measurements will be similar to that of Specific Aim I, but
conducted during periods of baseline health, acute exacerbation and recovery.
Specific Aim III tests whether airway surface hydration with Hypertonic Saline will restore
clearance in the basal state and during a COPD acute exacerbation. COPD subjects will be
exposed to inhaled Hypertonic Saline during periods of baseline health and acute
exacerbation. Acute efficacy via measures of mucus clearance and spirometry will studied.
Inclusion Criteria:
- history of COPD/chronic bronchitis defined as having a productive cough for three
months of the year for at least two successive years
- greater than or equal to a 10 pack year cigarette smoking history
- ability to perform spirometry
Exclusion Criteria:
- unstable lung disease
- allergy to study medications
- radiation exposure within past year exceeding Federal Regulation Limits
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