Collecting Stem Cells in Patients With Waldenstrom's Macroglobulinemia



Status:Recruiting
Conditions:Lymphoma, Hematology
Therapuetic Areas:Hematology, Oncology
Healthy:No
Age Range:18 - Any
Updated:4/2/2016
Start Date:November 2005

Use our guide to learn which trials are right for you!

Autologous Stem Cell Harvesting for Waldenstrom's Macroglobulinemia

RATIONALE: Collecting and storing stem cells to study in the laboratory may help doctors
learn more about collecting stem cells from patients who have undergone treatment for
Waldenstrom's macroglobulinemia.

PURPOSE: This laboratory study is collecting stem cells from patients with Waldenstrom's
macroglobulinemia.

OBJECTIVES:

- Harvest and store adequate CD34+ stem cells from patients with Waldenstrom's
macroglobulinemia (WM) for potential future use in transplantation strategies.

- Evaluate the ability to harvest stem cells after therapy for WM (e.g.,
fludarabine-based chemotherapy) by evaluating the number of days to adequate harvest.

- Collect aliquots of stem cells for future research analysis as part of a WM database
project.

OUTLINE: Patients undergo collection of autologous stem cells beginning on day 4 or 5 and
continuing until an adequate number of stem cells are collected. Cells are then
cryopreserved.

PROJECTED ACCRUAL: A total of 40 patients will be accrued for this study.

DISEASE CHARACTERISTICS:

- Diagnosis of Waldenstrom's macroglobulinemia (WM)

- Less than 30% lymphoplasmacytoid cells in bone marrow by histopathology

- Received prior chemotherapy for WM

PATIENT CHARACTERISTICS:

- ECOG performance status 0-1

- WBC > 2,000/mm³

- Platelet count > 50,000/mm³

- LVEF ≥ 50%

- No organ dysfunction that would preclude future transplantation

PRIOR CONCURRENT THERAPY:

- See Disease Characteristics
We found this trial at
1
site
701 West 168th Street
New York, New York 10032
(212) 851-4680
Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center The Herbert Irving Comprehensive Cancer...
1290
mi
from
New York, NY
Click here to add this to my saved trials