Safety and Tolerability Study of PCI-32765 Combined With Fludarabine/Cyclophosphamide/Rituximab (FCR) and Bendamustine/Rituximab (BR) in Chronic Lymphocytic Leukemia (CLL)



Status:Archived
Conditions:Blood Cancer, Lymphoma
Therapuetic Areas:Oncology
Healthy:No
Age Range:Any
Updated:7/1/2011
Start Date:February 2011
End Date:March 2013

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A Phase 1b, Multicenter, Open-label, Parallel-group Safety Study of a Bruton's Tyrosine Kinase (Btk) Inhibitor, PCI 32765, in Combination With Chemotherapy in Subjects With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma


The purpose of this study is to establish the safety of orally administered PCI-32765 in
combination with fludarabine/cyclophosphamide/rituximab (FCR) and bendamustine/rituximab
(BR) in patients with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma(SLL).


This is a Phase 1b, open-label, parallel-group, nonrandomized, multicenter study of PCI
32765 420 mg once daily oral (PO) administration in combination with 2 different
chemotherapy regimens in subjects with relapsed/refractory chronic lymphocytic leukemia
(CLL)/small lymphocytic lymphoma (SLL).


We found this trial at
7
sites
601 Elmwood Ave
Rochester, New York 14642
(585) 275-2100
Strong Memorial Hospital (University of Rochester School of Medicine) In addition to offering traditional and...
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Rochester, NY
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Boston, Massachusetts 02115
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Boston, MA
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Egleston, GA
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1515 Holcombe Blvd
Houston, Texas 77030
 713-792-2121
University of Texas M.D. Anderson Cancer Center The mission of The University of Texas MD...
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Houston, TX
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230 25th Ave N
Nashville, Tennessee 37203
(615) 329-7274
Sarah Cannon Cancer Center People who live with cancer
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Nashville, TN
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New Hyde Park, New York 11042
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New Hyde Park, NY
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New York, NY
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