A Study in Prevention of Re-emergence of Depression Symptoms

Inclusion Criteria:

- Outpatients with clinical diagnosis of Major Depressive Disorder (MDD)

- Using a reliable method of birth control

- Are taking an SSRI approved for MDD treatment within the patient's country and the
SSRI prescribed, including dose, should be consistent with labeling guidelines within
the participating country

- Have a partial response to SSRI treatment

- Meet inclusion scores on pre-defined psychiatric scales to assess diagnosis of
depression, disease severity, and response to SSRI treatment

- Reliable and able to keep all scheduled appointments

- Have had at least 1 previous episode of MDD prior to the current episode within the
past 5 years

Exclusion Criteria:

- Have had or currently have any additional ongoing Diagnostic and Statistical Manual
of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) Axis 1 condition other
than major depression within 1 year of screening

- Have a current or any previous diagnosis of a bipolar disorder, schizophrenia, or
other psychotic disorder

- Have a history of substance abuse and/or dependence within the past 1 year (drug
categories defined by DSM-IV-TR), not including caffeine and nicotine.

- Have an Axis II disorder that, in the judgment of the investigator, would interfere
with compliance with protocol

- Have any diagnosed medical condition which could be exacerbated by noradrenergic
agents including unstable hypertension, unstable heart disease, tachycardia,
tachyarrhythmia, narrow-angle glaucoma, history of urinary hesitation or retention

- Have initiated or discontinued hormone therapy (including, birth control, thyroid
hormone) within the previous 3 months prior to enrollment

- Have a lifetime history of vagal nerve stimulation (VNS), transcranial magnetic
stimulation (TMS), or psychosurgery

- Have received electroconvulsive therapy (ECT) in the past year

- Serious or unstable medical condition

- History of seizure disorders

- Have initiated psychotherapy, change in intensity of psychotherapy or other nondrug
therapies (such as acupuncture or hypnosis) within 6 weeks prior to enrollment or any
time during the study

- Patients who, in the opinion of the investigator, are judged to be at serious risk
for harm to self or others

- Are pregnant or breastfeeding

- Meets criteria for treatment-resistant depression