Progressive Weight Loss and Metabolic Health
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Obesity Weight Loss, Endocrine |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 21 - 65 |
| Updated: | 4/21/2016 |
| Start Date: | February 2011 |
| End Date: | July 2016 |
This study will evaluate the potential beneficial cardiometabolic effect of moderate (5%)
weight loss and progressive (5%, 10%, and 15%) weight loss in obese adults without diabetes.
Participants will be randomly assigned to one of 2 groups. Group 1: supervised weight loss
group (low-calorie diet). Group 2: supervised weight maintenance group (normal diet). Of
those assigned to group 1, half of the participants will lose 5% of their body weight and
the other half will lose 5%, 10%, and 15% of their weight over time under the guidance of a
dietitian. Research testing will be repeated at each time point (5%, 10%, and 15% weight
loss). In group 2, research testing will be repeated after six months.
weight loss and progressive (5%, 10%, and 15%) weight loss in obese adults without diabetes.
Participants will be randomly assigned to one of 2 groups. Group 1: supervised weight loss
group (low-calorie diet). Group 2: supervised weight maintenance group (normal diet). Of
those assigned to group 1, half of the participants will lose 5% of their body weight and
the other half will lose 5%, 10%, and 15% of their weight over time under the guidance of a
dietitian. Research testing will be repeated at each time point (5%, 10%, and 15% weight
loss). In group 2, research testing will be repeated after six months.
Inclusion Criteria:
- Obese: Body Mass Index from 30 to 45
- Insulin Resistant: HOMA-IR score greater than or equal to 2
Exclusion Criteria:
- diabetes
- smoking
- pregnancy
- breastfeeding
- heart failure
- history of liver disease including hepatitis
- alcoholism
- exercise more than 2 hours per week
We found this trial at
1
site
660 S Euclid Ave
Saint Louis, Missouri 63110
Saint Louis, Missouri 63110
(314) 362-5000
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
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