Muscle Atrophy, Physical Performance and Glucose Tolerance Post Stroke
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Neurology |
| Therapuetic Areas: | Neurology |
| Healthy: | No |
| Age Range: | 21 - Any |
| Updated: | 1/18/2019 |
| Start Date: | April 13, 2011 |
| End Date: | December 2019 |
Stroke, a leading cause of disability in the aging population, increases the risk for
diabetes, subsequent stroke recurrence, and cardiovascular disease complications. The
downsizing of private and federal health care resources, along with the anticipated increase
in stroke rates as our population ages, mandate that alternative strategies be developed to
reduce the public health burden of stroke. This pilot study may facilitate our knowledge of
the timing of paretic leg muscle atrophy, fiber type shift, and the progression of worsening
of glucose tolerance after stroke. Knowledge of the skeletal muscle changes occurring in the
sub-acute stroke period is essential to create new guidelines incorporating exercise
rehabilitation, much like cardiac rehabilitation, in order to facilitate and improve the
health care of veteran stroke survivors.
diabetes, subsequent stroke recurrence, and cardiovascular disease complications. The
downsizing of private and federal health care resources, along with the anticipated increase
in stroke rates as our population ages, mandate that alternative strategies be developed to
reduce the public health burden of stroke. This pilot study may facilitate our knowledge of
the timing of paretic leg muscle atrophy, fiber type shift, and the progression of worsening
of glucose tolerance after stroke. Knowledge of the skeletal muscle changes occurring in the
sub-acute stroke period is essential to create new guidelines incorporating exercise
rehabilitation, much like cardiac rehabilitation, in order to facilitate and improve the
health care of veteran stroke survivors.
The vast majority of cerebrovascular accidents are reported in persons older than 55 years of
age and occur in over 780,000 persons each year in the U.S. As our adult population ages, the
number of strokes in the United States is anticipated to double, reaching nearly 1.5 million
annually by the year 2050. Following stroke, patients remain at continued high risk for
recurrent stroke with almost a third of them suffering recurrent stroke within 5 years, even
despite optimal medical management. Age and cardiac disease are among the most important
longitudinal predictors of cardiovascular health outcomes and survival after stroke. Notably,
75% of chronic stroke survivors have residual disability emphasizing the need for
rehabilitation strategies.
Knowledge of the skeletal muscle changes that occur in the early phases after stroke is
essential to create new guidelines which incorporate exercise rehabilitation, much like
cardiac rehabilitation, in order to facilitate and improve the health care of stroke
survivors.
age and occur in over 780,000 persons each year in the U.S. As our adult population ages, the
number of strokes in the United States is anticipated to double, reaching nearly 1.5 million
annually by the year 2050. Following stroke, patients remain at continued high risk for
recurrent stroke with almost a third of them suffering recurrent stroke within 5 years, even
despite optimal medical management. Age and cardiac disease are among the most important
longitudinal predictors of cardiovascular health outcomes and survival after stroke. Notably,
75% of chronic stroke survivors have residual disability emphasizing the need for
rehabilitation strategies.
Knowledge of the skeletal muscle changes that occur in the early phases after stroke is
essential to create new guidelines which incorporate exercise rehabilitation, much like
cardiac rehabilitation, in order to facilitate and improve the health care of stroke
survivors.
Inclusion Criteria:
- Men or women 21 years of age or older
- BMI between 20-50 kg/m2
- Presenting within a month after stroke onset with residual hemiparetic deficit
- Patients must have adequate language and neurocognitive function to participate in
testing and give adequate informed consent
Exclusion Criteria:
- Patients deemed too disabled to participate in physical therapy, or patients with
minimal deficits, or patients who fully recovered after their stroke, in which
physical therapy is not necessary
- Unstable angina, CHF, severe PAD
- Dementia or untreated major depression
- Severe receptive or global aphasia
- Heavy alcohol use defined by greater than 3 oz. liquor, 12 oz of wine or 32 oz of beer
daily
- Muscle biopsy Exclusion Criteria:
- anti-coagulation therapy with heparin, warfarin, or lovenox (anti-platelet
therapy is permitted)
- bleeding disorder
- allergy to lidocaine
We found this trial at
3
sites
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials