The Effects of Omega-3 Fatty Acids Supplementation on Endothelial Function and Inflammation



Status:Recruiting
Conditions:Peripheral Vascular Disease
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:50 - Any
Updated:1/6/2018
Start Date:April 2011
End Date:December 2018
Contact:Sukaynah Khetani, BS
Email:sukaynah.khetani@ucsf.edu
Phone:415-353-4368

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The hypothesis being tested is that in patients with stable claudication and documented PAD,
omega-3 supplementation for 1 month will lead to improvement in endothelial function as
measured by flow-mediated, brachial artery vasodilation (FMD), as well as improvement in the
vascular inflammatory profile as measured by a panel of established circulating inflammatory
biomarkers.


Inclusion Criteria:

- intermittent claudication

- resting or exercise Ankle-Brachial Index (ABI) <0.9

- age 50 and more

Exclusion Criteria:

- critical limb ischemia

- hypersensitivity/allergies to fish or seafood

- already on omega-3 fatty acids or equivalent

- significant renal, hepatic, and inflammatory disease

- concurrent severe infections

- acute illness (MI, stroke, major surgery within 30 days)

- receiving immunosuppressive medications or steroids
We found this trial at
1
site
San Francisco, California 94143
Principal Investigator: Marlene Grenon, MD
Phone: 415-221-4810
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San Francisco, CA
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