Growing Right Onto Wellness (GROW): Changing Early Childhood Body Mass Index (BMI) Trajectories

Status:Active, not recruiting
Conditions:Obesity Weight Loss
Therapuetic Areas:Endocrinology
Age Range:3 - 5
Start Date:June 2011
End Date:July 2017

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The purpose of this study is to conduct a randomized controlled trial that examines how a
family based, community centered intervention effects early childhood BMI trajectories.

Increases in sedentary lifestyle and high calorie food consumption, among other factors,
have contributed to epidemic levels of childhood obesity in the US. Children who are
overweight during the preschool period are more likely to become overweight adolescents and
obese adults. Food preferences and activity habits set in early childhood can profoundly
influence lifelong trajectories for Body Mass Index (BMI) and health. Specifically, rapid
BMI gain in early childhood has been established to affect adulthood mortality and
morbidity. Unfortunately, the longer such unhealthy patters are in place, the more difficult
it can be to reverse them. Therefore, healthy lifestyle interventions targeted at children
as early as preschool have enormous potential to affect lifelong health. Furthermore,
nutrition and activity patterns are determined not only at the child level, but within the
family and the community.

This study will assess the impact of a family-based and community centered multilevel
behavioral intervention addressing nutrition and physical activity with high risk
parent-preschool children dyads to promote pediatric obesity prevention. The 7 year study
will follow 600 parent preschool child dyads, half of whom will be randomized into the
intervention condition which will utilize a health literate approach, build new social
networks, utilize behavior modification tools including goal setting, self monitoring, and
problem solving, and create behavior-environmental synergy with cues to action for use of
the built environment for healthy behaviors. Both the intervention and control group
(separately) will receive the control condition in which parent-child dyads will receive a
literacy promotion/school success curriculum.

The primary outcome of interest will be early childhood BMI trajectories measured at
multiple time points over the three year RCT. Additional measures collected throughout the
study from children and parents will include: tricep skin fold, waist circumference,
actigraphy, 3-day diet recalls, questionnaires, social network data, and saliva to assess a
genetics/epigenetics associated with obesity. Consistent with a multilevel systems approach,
the investigators will develop and assess policy changes around obesity prevention.
Moreover, working with the study's community partners, the investigators will evaluate how
this approach affects local policy.

Inclusion Criteria:

- English or Spanish speaking

- Address in select zip code regions around participating Metro community centers

- Parental commitment to consistent participation

- Consistent phone access for 3 years

- Child aged 3-5 years old

- Child BMI ≥ 50% and < 95% (no diagnosis of failure to thrive or difficulty with
appropriate weight gain)

- Healthy parent and child (without medical conditions necessitating limited physical

- Parent ≥ 18 years of age

Exclusion Criteria:

- Non English or Spanish speaking

- Address outside select zip code regions around participating Metro community centers

- Lack of parental commitment to consistent participation

- Lack of consistent phone access

- Child outside specified age range

- Child BMI < 50% or ≥ 95%

- Parents and/or children who are diagnosed with medical illnesses where regular
exercise might be contraindicated

- Parent < 18 years of age
We found this trial at
1211 Medical Center Dr
Nashville, Tennessee 37232
(615) 322-5000
Vanderbilt Univ Med Ctr Vanderbilt University Medical Center (VUMC) is a comprehensive healthcare facility dedicated...
Nashville, TN
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