Cell Responses to IFN-gamma
| Status: | Archived |
|---|---|
| Conditions: | Psoriasis |
| Therapuetic Areas: | Dermatology / Plastic Surgery |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | July 2010 |
| End Date: | March 2012 |
Cellular Responses To Intradermal-Gamma (IFN-gamma) in Normal and Psoriatic Patients
IFN-gamma is a central player in the development of psoriasis lesions, which can be involved
a variety of cellular processes in the skin. Dendritic cells are important cells in driving
inflammation in psoriasis through the induction of T cells that produce IL-17 in psoriasis.
Injecting IFN-g into the skin can increase the numbers of T cells and also inflammatory DCs
that produce cytokines involved in IL-17 production. Thus, the investigators hypothesize
that the dendritic cells present in the skin after IFN-g injection polarize IL-17-producing
T cells.
We found this trial at
1
site
Click here to add this to my saved trials
